Browsing by Author "Zago, M. Paola"

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    • A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured trypanosoma cruzi strain, ... 
      Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Ramírez Toloza, Galia; Uncos, Alejandro D.; Zago, M. Paola; Cimino, Rubén O.; Cardozo, Rubén M.; Marco, Jorge D.; Ferreira Vigouroux, Luis Arturo; Basombrío, Miguel Angel (PLOS Neglected Tropical Diseases, 2014-02)
      Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite ...
    • Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to ... 
      Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Zago, M. Paola; Labriola, Carlos; Ferreira, Arturo; Basombrío, Miguel Ángel (2013-03)
      Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in ...