Browsing by Subject "Ascorbate"

Now showing items 1-4 of 4

    • Ascorbate as a bioactive compound in cancer therapy: the old classic strikes back 
      González Montero, Jaime; Chichiarelli, Silvia; Eufemi, Margherita; Altieri, Fabio; Saso, Luciano; Rodrigo Salinas, Ramón (MDPI, 2022)
      Cancer is a disease of high mortality, and its prevalence has increased steadily in the last few years. However, during the last decade, the development of modern chemotherapy schemes, new radiotherapy techniques, targeted ...
    • Effect of ascorbate in the reduction of transferrin-associated iron in endocytic vesicles 
      Escobar, Aldo; Gaete, Victoria; Núñez González, Marco (Kluwer Academic Publishers-Plenum Publishers, 1992)
      Externally added ascorbate or NADH effectively reduced ferricyanide and promoted the exit of Fe3+ originated from acid-destabilized transferrin contained inside endocytic vesicles. The effect of ascorbate was mediated by ...
    • Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies 
      Beck, R.; Dejeans, N.; Glorieux, C.; Pedrosa, R. C.; Vósquez, D.; Valderrama, J. A.; Calderon, P. B.; Verrax, J. (2011)
      Hsp90 is a molecular chaperone involved in the stabilization of many oncoproteins that are required for the acquisition and maintenance of the so-called six major hallmarks of cancer cells. Various strategies have, therefore, ...
    • Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide 
      Aliaga, Margarita E.; López Alarcón, Camilo; García Río, Luis; Martín-Pastor, Manuel; Speisky Cosoy, Hernán (2012)
      The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH] 2) has the ability to reduce molecular oxygen into superoxide. Removal of such radicals leads to the irreversible conversion of Cu(I)-[GSH] 2 into the ...