Browsing by Subject "Brain"

Now showing items 1-20 of 26

    • Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 ... 
      Pelgrim, Teuntje A. D.; Bossong, Matthijs G.; Cuiza, Analía; Alliende, Luz María; Mena, Carlos; Tepper, Ángeles; Ramírez Mahaluf, Juan Pablo; Iruretagoyena, Bárbara; Ornstein Letelier, Claudia; Fritsch Montero, Rosemarie Mónica; Cruz, Juan Pablo; Tejos, Cristian; Repetto, Gabriela; Crossley, Nicolás (Nature, 2021)
      The 22q11 deletion syndrome is a genetic disorder associated with a high risk of developing psychosis, and is therefore considered a neurodevelopmental model for studying the pathogenesis of schizophrenia. Studies have ...
    • Adolescent oomnternalizing, externalizing, and social problems following iron deficiency at 12–18 months: ... 
      Doom, Jenalee; Gahagan, Sheila; East, Patricia; Encina Moreno, Pamela; Delva, Jorge; Lozoff, Betsy (Wiley, 2020)
      This study tested whether maternal responsiveness moderated or mediated pathways from iron deficiency (ID) at 12-18 months to adolescent behavior problems. Participants were part of a large Chilean cohort (N = 933). Iron ...
    • Brain and liver lipid peroxidation levels following acute and short-term lindane administration in the rat 
      Arisi, Ana Carolina M.; Kiyoko, Simizu; Marisa, Kogake; Barny, Afonso C.D.; Silva, Marcia A.S.; Barros, Silvia B.M.; Boveris, Alberto; Videla Cabrera, Luis; Junqueira, Virginia (1994)
      Oxidative stress-related parameters in rat brain and liver were evaluated following acute (60 mg/kg i.p., 2 and 24 h after dosing) or short-term (1000 ppm in the diet for 90 days) lindane administration. Both treatments ...
    • Brain development parameters and intelligence in Chilean high school graduates 
      Ivanovic, Daniza M.; Leiva, Boris P.; Castro, Carmen G.; Olivares, Manuel G.; Jansana, Joan Manuel M.; Castro, Verónica G.; Almagià, Atillo Aldo F.; Toro, Triana D.; Urrutia, María Soledad C.; Miller, Patricio T.; Bosch, Enrique O.; Larraín, Cristián G.; Pérez, Herná (2004)
      The hypothesis that independently of sex, brain volume (BV) and head circumference (HC) are positively and significantly associated with intellectual quotient (IQ) was examined in a sample of 96 high school graduates of ...
    • Chaski, a novel drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional ... 
      Delgado, María Graciela; Oliva, Carlos; López, Estefanía; Ibacache, Andrés; Galaz, Alex; Delgado, Ricardo; Barros, L. Felipe; Sierralta, Jimena (Nature Publishing Group, 2018)
      The intercellular transport of lactate is crucial for the astrocyte-to-neuron lactate shuttle (ANLS), a model of brain energetics according to which neurons are fueled by astrocytic lactate. In this study we show that the ...
    • Cloning of hif-1α and hif-2α and mRNA expression pattern during development in zebrafish 
      Rojas, Diego A.; Pérez Munizaga, Daniela A.; Centanin, Lazaro; Antonelli, Marcelo; Wappner, Pablo; Allende Connelly, Miguel; Reyes, Ariel E. (2007)
      Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in vertebrates they are known to participate in several developmental processes, including angiogenesis, vasculogenesis, heart and central ...
    • Delta band activity contributes to the identification of command following in disorder of consciousness 
      Rivera Lillo, Gonzalo Bernardo; Stamatakis, Emmanuel; Bekinschtein, Tristan A.; Menon, David K.; Chennu, Srivas (Nature, 2021)
      The overt or covert ability to follow commands in patients with disorders of consciousness is considered a sign of awareness and has recently been defined as cortically mediated behaviour. Despite its clinical relevance, ...
    • Directly reprogrammed human neurons to understand age-related energy metabolism impairment and mitochondrial ... 
      Gudenschwager Ruiz, Camila Andrea; Chávez, Isadora; Cárdenas, César; González Billault, Christian Enrique (Hindawi, 2021)
      Brain aging is characterized by several molecular and cellular changes grouped as the hallmarks or pillars of aging, including organelle dysfunction, metabolic and nutrition-sensor changes, stem cell attrition, and ...
    • Endogenous ligands for the quisqualate receptor: presence in rat brain cortex synaptic vesicles 
      Villanueva,; Orrego, (1988)
      The presence in highly purified rat brain cortex synaptic vesicles of endogenous ligands for rat brain quisqualate receptors was investigated. The vesicles were extracted, and their contents fractionated by high voltage ...
    • Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion 
      Cleynen, Isabelle; Engchuan, Worrawat; Hestand, Matthew S.; Heung, Tracy; Holleman, Aarón M.; Johnston, H. Richard; Monfeuga, Thomas; McDonald McGinn, Donna M.; Gur, Raquel E.; Morrow, Bernice E.; Swillen, Ann; Vorstman, Jacob A. S.; Bearden, Carrie E.; Chow, Eva W. C.; van den Bree, Marianne; Emanuel, Beverly S.; Vermeesch, Joris R.; Warren, Stephen T.; Owen, Michael J.; Chopra, Pankaj; Cutler, David J.; Duncan, Richard; Kotlar, Alex V.; Mulle, Jennifer G.; Voss, Anna J.; Zwick, Michael E.; Diacou, Alexander; Golden, Aaron; Guo, Tingwei; Lin, Jhih Rong; Wang, Tao; Zhang, Zhengdong; Zhao, Yingjie; Marshall, Christian; Merico, Daniele; Jin, Andrea; Lilley, Brenna; Salmons, Harold I.; Oanh, Tran; Pardinas, Antonio; Walters, James T. R.; Demaerel, Wolfram; Boot, Erik; Butcher, Nancy J.; Costain, Gregory A.; Lowther, Chelsea; Evers, Rens; van Amelsvoort, Therese A. M. J.; van Duin, Esther; Vingerhoets, Claudia; Breckpot, Jeroen; Devriendt, Koen; Vergaelen, Elfi; Vogels, Annick; Crowley, T. Blaine; McGinn, Daniel E.; Moss, Edward M.; Sharkus, Robert J.; Unolt, Marta; Zackai, Elaine H.; Calkins, Mónica E.; Gallagher, Robert S.; Gur, Rubén C.; Tang, Sunny X.; Fritsch Montero, Rosemarie; Ornstein Letelier, Claudia; Repetto, Gabriela M.; Breetvelt, Elemi; Duijff, Sasja N.; Fiksinski, Ania; Moss, Hayley; Niarchou, Maria; Murphy, Kieran C.; Prasad, Sarah E.; Daly, Eileen M.; Gudbrandsen, María; Murphy, Clodagh M.; Murphy, Declan G.; Buzzanca, Antonio; Di Fabio, Fabio; Digilio, María C.; Pontillo, María; Marino, Bruno; Vicari, Stefano; Coleman, Karlene; Cubells, Joseph F.; Ousley, Opal Y.; Carmel, Miri; Gothelf, Doron; Mekori Domachevsky, Ehud; Michaelovsky, Elena; Weinberger, Ronnie; Eliez, Stephan; Sandini, Corrado; Schneider, Maude; Bena, Frederique Sloan; Antshel, Kevin M.; Fremont, Wanda; Kates, Wendy R.; Belzeaux, Raoul; Busa, Tiffany; Schoch, Kelly; Shashi, Vandana; Simon, Tony J.; Tassone, Flora; Arango, Celso; Suner, Damia H.; Raventos Simic, Jasna; Epstein, Michael P.; Williams, Nigel M.; Bassett, Anne S. (Nature, 2020)
      Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of ... 
      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • In situ rat brain and liver spontaneous chemiluminescence after acute ethanol intake 
      Boveris, Alberto; Llesuy, Susana; Azzalis, Ligia A.; Giavarotti, Leandro; Simon, Karin A.; Junqueira, Virginia; Porta, Eduardo A.; Videla Cabrera, Luis; Lissi Gervaso, Eduardo A. (1997)
      The influence of acute ethanol administration on the oxidative stress status of rat brain and liver was assessed by in situ spontaneous organ chemiluminescence (CL). Brain and liver CL was significantly increased after ...
    • Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol ... 
      Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature, 2018)
      Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
    • Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned ... 
      Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library Science, 2015)
      Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover ...
    • Is the kisspeptin system involved in responses to food restriction in order to preserve reproduction in ... 
      Escobar, Sebastián; Felip, Alicia; Zanuy, Silvia; Carrillo, Manuel (Elsevier, 2016)
      Previous works on European sea bass have determined that long-term exposure to restrictive feeding diets alters the rhythms of some reproductive/metabolic hormones, delaying maturation and increasing apoptosis during ...
    • Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer 
      Catalán Figueroa, Johanna; Palma Florez, Sujey; Alvarez, Gonzalo; Fritz, Hans F.; ara, Miguel O.; Morales, Javier O. (Future Medicine Ltd., 2016)
      Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their pharmacokinetic ...
    • Nighttime sleep characteristics and white matter integrity in young adults 
      Reyes García, Sussanne Carola; Medeiros Rimkus, Carolina de; Lozoff, Betsy; Algarin Crespo, Cecilia Rosa; Peirano Campos, Patricio Darío (Dove Medical Press Ltd, New Zealand, 2022)
      Purpose: Sleep is essential for life and plays a key role for optimal physiology, brain functioning, and health. Evidence suggests a relation between sleep and cerebral white matter integrity. Human studies report that ...
    • NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, ... 
      Bustos, Fernando J.; Jury, Nur; Martínez, Pablo; Ampuero, Estibaliz; Campos, Matías; Abarzua, Sebastián; Jaramillo, Karen; Ibing, Susanne; Mardones, Muriel D.; Haensgen, Henny; Kzhyshkowska, Julia; Tevy, María Florencia; Neve, Rachael; Sanhueza Toha, María Magdalena; Varela Nallar, Lorena; Montecino, Martín; Van Zundert, Brigitte (Wiley, 2017)
      Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and ...
    • Nutritional status, brain development and scholastic achievement of Chilean high-school graduates from high ... 
      Ivanovic, Daniza M.; Leiva, Boris P.; Pérez, Hernán T.; Almagià, Atilio F.; Toro, Triana D.; Urrutia, María Soledad C.; Inzunza, Nélida B.; Bosch, Enrique O. (2002)
      The objective of the present study was to investigate the inter-relationships between nutritional status (past and current nutrition), brain development, and scholastic achievement (SA) of Chilean high-school graduates ...
    • Potential effects of reward and loss avoidance in overweight adolescents 
      Reyes, Sussanne; Peirano Campos, Patricio; Luna, Beatriz; Lozoff, Betsy; Algarín Crespo, Cecilia Rosa (Nature Publishing, 2015)
      BACKGROUND: Reward system and inhibitory control are brain functions that exert an influence on eating behavior regulation. We studied the differences in inhibitory control and sensitivity to reward and loss avoidance ...