Browsing by Subject "CDK5"

Now showing items 1-3 of 3

    • CDK5: A Unique CDK and Its Multiple Roles in the Nervous System 
      Cortés, Nicole; Guzmán Martínez, Leonardo; Andrade, Víctor; González, Andrea; Maccioni Baraona, Ricardo (IOS Press, 2019)
      The cyclin-dependent kinase 5 (CDK5) is known as an exceptional component of the CDK family, due to its characteristic regulatory pathways and its atypical roles in comparison to the classical cyclins. Despite its functional ...
    • p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease 
      Uribe Arias, Alejandro; Posada Duque, Rafael Andres; González Billault, Christian; Villegas, Andrés; Lopera, Francisco; Cardona Gómez, Gloria Patricia (Wiley-Blackwell, 2016)
      Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's disease. Our previous studies revealed that ...
    • p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing 
      Posada Duque, Rafael; López Tobon, Alejandro; Piedrahita, Diego; González Billault, Christian; Cardona Gómez, Gloria (Wiley & Sons, 2015)
      CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we ...