Browsing by Subject "Cdk5"

Now showing items 1-8 of 8

    • Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth 
      Furusawa, Kotaro; Asada, Akiko; Urrutia, Pamela; González Billault, Christian; Fukuda, Mitsunori; Hisanaga, Shin-ichi (Society for Neuroscience, 2017)
      Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
    • Conditional TNF-alpha Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis 
      Hall, B.E.; Zhang, L.; Sun, Z. J.; Utreras Puratich, Elías; Prochazkova, M.; Cho, A.; Terse, A.; Arany, P.; Dolan, J. C.; Schmidt, B. L.; Kulkarni, A. B. (International & American Associations for Dental Research, 2016)
      Tumor necrosis factor-alpha(TNF-alpha) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-alpha expression not only promotes inflammation but can also lead to pain hypersensitivity in nociceptors. ...
    • Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis 
      Hall, B. E.; Zhang, L.; Sun, Z. J.; Utreras Puratich, Elías; Prochazkova, M.; Cho, A.; Terse, A.; Arany, P.; Dolan, J. C.; Schmidt, B. L.; Kulkarni, A. B. (SAGE Publications Inc., 2016)
      © International & American Associations for Dental Research 2015. Tumor necrosis factor-α (TNF-α) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-α expression not only promotes inflammation ...
    • Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5 
      Contreras Vallejos, Erick; Utreras Puratich, Elías; González Billault, Christian (Elsevier, 2012)
      Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal ...
    • Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist ... 
      Utreras Puratich, Elías; Hamada, Ryusuke; Prochazkova, Michaela; Terse, Anita; Takahashi, Satoru; Ohshima, Toshio; Kulkarni, Ashok B. (BioMed Central Ltd., 2014)
      Background: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific ...
    • Targeted overexpression of tumor necrosis factor-a increases cyclin-dependent kinase 5 activity and ... 
      Rozas, Pablo; Lazcano, Pablo; Piña, Ricardo; Cho, A.; Terse, Anita; Pertusa, María; Madrid, Rodolfo; González Billault, Christian; Kulkarni, Ashok B.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2016)
      We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
    • TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells 
      Utreras Puratich, Elías; Prochazkova, Michaela; Terse, Anita; Gross, Jacklyn; Keller, Jason; Iadarola, Michael J.; Kulkarni, Ashok B. (2013)
      Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...
    • TNF-α increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons 
      Sandoval Guzmán, Rodrigo; Lazcano Sánchez, Pablo; Ferrari Soto, Franco; Pinto Pardo, Nicolás; González Billault, Christian; Utreras Puratich, Elías (Frontiers Media, 2018)
      The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...