Browsing by Subject "DT-diaphorase"
Now showing items 1-7 of 7
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(Bentham Science, 2016)The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...
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(Bentham Science Publishers B.V., 2016)© 2016 Bentham Science Publishers.The pharmacological treatment of Parkinsońs disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. LDopa was introduced to the ...
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(Impact Journals LLC, 2017)
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(2011)Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
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(2002)Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
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(Springer, 2023)Dopamine’s ability to oxidize to aminochrome explains why this molecule may be a neurotoxic compound that induces toxicity in both cell lines and animal models. Spontaneous dopamine oxidation is prevented by vesicular ...
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(2012)We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...