Browsing by Subject "Differentiation"

Now showing items 1-13 of 13

    • Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the ... 
      Peñailillo, Johany; Palacios, Miriam; Mounieres, Constanza; Muñoz Videla, Rosana del Valle; Slater, Paula G.; Doménico, Elena de; Patrushev, Ilya; Gilchrist, Mike; Larraín, Juan (Nature, 2021)
      Xenopus laevis are able to regenerate the spinal cord during larvae stages through the activation of neural stem progenitor cells (NSPCs). Here we use high-resolution expression profiling to characterize the early ...
    • CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression 
      Bono Merino, María Rosa; Fernández, Dominique; Flores Santibáñez, Felipe; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Elsevietr, 2015)
      Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
    • Directly reprogrammed human neurons to understand age-related energy metabolism impairment and mitochondrial ... 
      Gudenschwager Ruiz, Camila Andrea; Chávez, Isadora; Cárdenas, César; González Billault, Christian Enrique (Hindawi, 2021)
      Brain aging is characterized by several molecular and cellular changes grouped as the hallmarks or pillars of aging, including organelle dysfunction, metabolic and nutrition-sensor changes, stem cell attrition, and ...
    • In Vitro Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds 
      Wahl, Elizabeth A.; Fierro, Fernando A.; Peavy, Thomas R.; Hopfner, Úrsula; Dye, Julian F.; Machens, Hans Günther; Egaña, José T.; Schenck, Thilo L. (Hindawi, 2015)
      Mesenchymal stemcells (MSCs) have been shown to improve tissue regeneration in several preclinical and clinical trials. These cells have been used in combination with three-dimensional scaffolds as a promising approach in ...
    • Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in ... 
      Rosser, Elizabeth C.; Piper, Christopher J. M.; Matei, Diana E.; Blair, Paul A.; Rendeiro, André F.; Orford, Michael; Alber, Dagmar G.; Krausgruber, Thomas; Catalán Martina, Diego; Klein, Nigel; Manson, Jessica J.; Drozdov, Ignat; Bock, Christoph; Wedderburn, Lucy R.; Eaton, Simon; Mauri, Claudia (Cell Press, 2020)
      The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance of tolerance. However, whether microbiota-derived metabolites can modulate Breg ...
    • Morphometrical and molecular evidence suggests cryptic diversity among hookworms (Nematoda: Uncinaria) that ... 
      González, M. T.; López, Zambra; Nuñez, J. J.; Calderón Mayo, K. I.; Ramírez, C.; Morgades, D.; Katz, H.; George-Nascimento, M.; Pavés, H. (Cambridge Univ Press, 2020)
      Hookworms of the genus Uncinaria parasitize pinniped pups in various locations worldwide. Four species have been described, two of which parasitize pinniped pups in the southern hemisphere: Uncinaria hamiltoni parasitizes ...
    • Partitioning β-diversity reveals that invasions and extinctions promote the biotic homogenization of Chilean ... 
      Castro, Sergio A.,; Rojas Venegas, Pablo; Vila Pinto, Irma; Habit, Evelyn; Pizarro Konczak, Jaime; Abades, Sebastián; Jaksic, Fabián M. (Public Library Science, 2020)
      Aim Exotic species' introductions together with extinction of native species represent the main mechanisms driving biotic homogenization of freshwater fish assemblages around the world. While generally ichtyofaunistic ...
    • PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response 
      Gupta, Ananya; Mosaraf Hossain, Muhammad; Read, Danielle E.; Hetz Flores, Claudio; Samali, Afshin; Gupta, Sanjeev (Nature, 2015)
      The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...
    • Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling 
      Nasirzade, Jila; Kargarpour, Zahra; Mitulović, Goran; Strauss Avendaño, Franz Josef; Panahipour, Layla; Schwarz, Frank; Gruber, Reinhard (Nature, 2021)
      Particulate autologous tooth roots are increasingly used for alveolar bone augmentation; however, the proteomic profile of acid dentin lysate and the respective cellular response have not been investigated. Here we show ...
    • Range-wide genetic structure in the thorn-tailed rayadito suggests limited gene flow towards peripheral populations 
      Botero Delgadillo, Esteban; Quirici, Verónica; Poblete, Yanina; Acevedo, Matías; Cuevas, Elfego; Bravo, Camila; Cragnolini, Margherita; Rozzi, Ricardo; Poulin, Elie; Mueller, Jakob C.; Kempenaers, Bart; Vásquez Morales, Rodrigo (Nature, 2020)
      Understanding the population genetic consequences of habitat heterogeneity requires assessing whether patterns of gene flow correspond to landscape configuration. Studies of the genetic structure of populations are still ...
    • TGFβ activity released from platelet-rich fibrin adsorbs to titanium surface and collagen membranes 
      Di Summa, Francesca; Kargarpour, Zahra; Nasirzade, Jila; Stähli, Alexandra; Mitulović, Goran; Panić Janković, Tanja; Koller, Veronika; Kaltenbach, Cosima; Müller, Heinz; Panahipour, Layla; Gruber, Reinhard; Strauss, Franz Josef (Nature, 2020)
      Platelet-rich fibrin (PRF) contains a broad spectrum of bioactive molecules that can trigger several cellular responses. However, these molecules along with their upstream responses remain mostly uninvestigated. By means ...
    • The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by ... 
      Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto Alarcón, Sandra A.; Ortiz, Macarena; Campos, Cristian; Vargas, Romina; Videla Cabrera, Luis (Royal Society of Chemistry, 2020)
      Background: Nutritional interventions are promising tools for the prevention of obesity. The n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) docosahexaenoic acid (DHA) modulates immune and metabolic responses while ...
    • β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation 
      Pinto, Cristina; Medinas, Danilo B.; Fuentes Villalobos, Francisco; Maripillán, Jaime; Castro, Ariel F.; Martínez, Agustín D.; Osses, Nelson; Hetz Flores, Claudio; Henríquez, Juan P. (Academic Press Inc., 2019)
      Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...