Browsing by Subject "Dihydroxynaphthyl aryl ketones"

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    • Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly 
      Gutiérrez, Eunices; Benites, Julio; Valderrama, Jaime; Buc Calderón, Pedro; Verrax, Julien; Nova Martínez, Esteban; Villanelo Lizana, Felipe; Maturana Middleton, Daniel; Escobar, Cristian; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (Elsevier, 2015)
      Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
    • Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones 
      Benites, Julio; Valderrama, Jaime A.; Ríos, David; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio; Buc Calderón, Pedro (2016)
      Dihydroxynaphthyl aryl ketones 1-5 exhibit activity as tubulin polymerization inhibitors by targeting the colchicine binding site of microtubules making them potential anticancer drugs. Therefore, analogues 1-5 have been ...