Browsing by Subject "Dihydroxynaphthyl aryl ketones"
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Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly (Elsevier, 2015)Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
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(2016)Dihydroxynaphthyl aryl ketones 1-5 exhibit activity as tubulin polymerization inhibitors by targeting the colchicine binding site of microtubules making them potential anticancer drugs. Therefore, analogues 1-5 have been ...