Browsing by Subject "Docking studies"

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    • A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo 
      Zarate, Ana María; Espinosa Bustos, Christian; Guerrero, Simón; Fierro, Angélica; Oyarzún Ampuero, Felipe; Geoffery Quest, Andrew; Di Marcotullio, Lucía; Loricchio, Elena; Caimano, Miriam; Calcaterra, Andrea; González Quiroz, Matías; Aguirre, Adam; Meléndez, Jaime; Salas, Cristian O. (MDPI, 2021)
      The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
    • Analysis of carotenoids in haloarchaea species from Atacama saline lakes by high resolution UHPLC-Q-Orbitrap-Mass ... 
      Lizama, Catherine; Romero Parra, Javier Hernán; Andrade, Daniel; Riveros, Felipe; Bórquez, Jorge; Ahmed, Shakeel; Venegas Salas, Luis; Cabalín, Carolina; Simirgiotis, Mario J. (MDPI, 2021)
      Haloarchaea are extreme halophilic microorganisms belonging to the domain Archaea, phylum Euryarchaeota, and are producers of interesting antioxidant carotenoid compounds. In this study, four new strains of Haloarcula sp., ...