Browsing by Subject "Drp1"

Now showing items 1-4 of 4

    • Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA ... 
      Sotomayor Flores, Cristian; Rivera Mejías, Pablo; Vásquez Trincado, César; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Polakovicova, Iva; Aliaga Tobar, Víctor; García Nannig, Lorena; Roa, Juan Carlos; Rothermel, Beverly A.; Maracaja Coutinho, Vinicius; Ho-Xuan, Hung; Meister, Gunter; Chiong, Mario; Ocaranza, María Paz; Corvalán, Alejandro H.; Parra Ortiz, Valentina; Lavandero González, Sergio (2020)
      Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics ... 
      Torres, Gloria; Morales, Pablo E.; García Miguel, Marina; Norambuena Soto, Ignacio; Cartes Saavedra, Benjamin; Vidal Pena, Gonzalo; Moncada Ruff, David; Sanhueza Olivares, Fernanda; San Martín, Alejandra; Chiong Lay, Mario (PERGAMON-ELSEVIER SCIENCE LTD., 2016)
      Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone produced by gastrointestinal tract in response to food ingestion. GLP-1 plays a very important role in the glucose homeostasis by stimulating glucose-dependent ...
    • Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway 
      Pennanen, Christian; Parra, Valentina; López Crisosto, Camila; Morales, Pablo E.; del Campo, Andrea; Gutierrez, Tomás; Rivera Mejías, Pablo; Kuzmicic, Jovan; Chiong Lay, Mario; Zorzano, Antonio; Rothermel, Beverly A.; Lavandero González, Sergio (Company of Biologists Ltd, 2014)
      Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...