Browsing by Subject "GABAAreceptor"

Now showing items 1-3 of 3

    • Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation ... 
      Tretter, Verena; Revilla-Sanchez, Raquel; Houston, Catriona; Terunuma, Miho; Havekes, Robbert; Florian, Cédrick; Jurd, Rachel; Vithlani, Mansi; Michels, Guido; Couve, Andrés; Sieghart, Werner; Brandon, Nicholas; Abel, Ted; Smart, Trevor G.; Moss, Stephen J. (2009)
      Fast synaptic inhibition in the brain is largely mediated by γ-aminobutyric acid receptors (GABAAR). While the pharmacological manipulation of GABAAR function by therapeutic agents, such as benzodiazepines can have profound ...
    • Gabapentin increases expression of δ subunit-containing GABA A receptors 
      Yu, Jieying; Wang, Dian Shi; Bonin, Robert P.; Penna Silva, Antonello; Alavian-Ghavanini, Ali; Zurek, Agnieszka A.; Rauw, Gail; Baker, Glen B.; Orser, Beverley A. (Elsevier, 2019)
      Background: Gabapentin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its anticonvulsant, analgesic and anxiolytic properties suggest that it increases GABAergic inhibition; however, ...
    • Synthesis and GABA(A) receptor activity of oxygen-bridged neurosteroid analogs 
      Alvarez, Lautaro D.; Veleiro, Adriana S.; Baggio, Ricardo F.; Garland, María Teresa; Edelsztein, Valeria C.; Coirini, Héctor; Burton, Gerardo (2008)
      Three analogs of neuroactive steroids were prepared (4-6) in which 1,11- or 11,19-oxygen bridges give a constrained conformation. Their 3D structures were obtained by ab initio calculations and in the case of 3 ...