Browsing by Subject "Heme"

Now showing items 1-5 of 5

    • A tRNA(Glu) that uncouples protein and tetrapyrrole biosynthesis 
      Levicán, Gloria; Katz, Assaf; Valenzuela, Patricio; Söll, Dieter; Orellana, Omar (2005)
      Glu-tRNA is either bound to elongation factor Tu to enter protein synthesis or is reduced by glutamyl-tRNA reductase (GluTR) in the first step of tetrapyrrole biosynthesis in most bacteria, archaea and in chloroplasts. ...
    • Effect of hydrogen peroxide on the biosynthesis of heme and proteins: Potential implications for the ... 
      Farah, Carolina; Levicán, Gloria; Ibba, Michael; Orellana, Omar (MDPI AG, 2014)
      © 2014 by the authors; licensee MDPI, Basel, Switzerland. Glutamyl-tRNA (Glu-tRNAGlu) is the common substrate for both protein translation and heme biosynthesis via the C5 pathway. Under normal conditions, an adequate ...
    • Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders 
      Mena, Natalia P.; Urrutia, Pamela J.; Lourido, Fernanda; Carrasco, Carlos M.; Núñez González, Marco (Elsevier, 2015)
      Synthesis of the iron-containing prosthetic groups—heme and iron–sulfur clusters—occurs in mitochondria. The mitochondrion is also an important producer of reactive oxygen species (ROS), which are derived fromelectrons leaking ...
    • Non-heme iron as ferrous sulfate does not interact with heme iron absorption in humans 
      Gaitán, Diego; Olivares, Manuel; Lönnerdal, Bo; Brito, Alex; Pizarro Aguirre, Fernando (2012)
      The absorption of heme iron has been described as distinctly different from that of non-heme iron. Moreover, whether heme and non-heme iron compete for absorption has not been well established. Our objective was to investigate ...
    • Redox status affects the catalytic activity of glutamyl-tRNA synthetase 
      Katz, Assaf; Banerjee, Rajat; de Armas, Merly; Ibba, Michael; Orellana, Omar (Academic Press Inc., 2010)
      Glutamyl-tRNA synthetases (GluRS) provide Glu-tRNA for different processes including protein synthesis, glutamine transamidation and tetrapyrrole biosynthesis. Many organisms contain multiple GluRSs, but whether these ...