Browsing by Subject "Lysosome"

Now showing items 1-4 of 4

    • Getting intimate: lysosomes and ER rendezvous to control autophagy 
      Pihán, Philippe; Hetz Flores, Claudio (Elsevier, 2020)
      The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 -a putative ER calcium channel and cell death regulator-promotes calcium transfer from the ER to lysosomes to induce ...
    • New molecular and organelle alterations linked to down syndrome heart disease 
      Venegas Zamora, Leslye Paola; Bravo Acuña, Francisco Javier; Sigcho Garrido, Francisco Javier; Gómez Calderón, Wileidy; Bustamante Salazar, José Brayan; Pedrozo Cibils, Zully; Parra Ortiz, Valentina María (Frontiers Media, 2022)
      Down syndrome (DS) is a genetic disorder caused by a trisomy of the human chromosome 21 (Hsa21). Overexpression of Hsa21 genes that encode proteins and non-coding RNAs (ncRNAs) can disrupt several cellular functions and ...
    • Palmitic and stearic acids inhibit chaperone-mediated autophagy (CMA) in POMC-like neurons In vitro 
      Espinosa Lemunao, Rodrigo; Gutiérrez, Karla; Ríos Castillo, Javiera; Ormeño, Fernando; Yantén, Liliana; Galaz Davison, Pablo; Ramírez Sarmiento, César; Parra Ortiz, Valentina; Albornoz, Amelina; Alfaro, Iván E.; Burgos, Patricia; Morselli, Eugenia; Criollo Céspedes, Alfredo; Budini, Mauricio (MDPI, 2022)
      The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...
    • Perspectives on organelle interaction, protein dysregulation, and cancer disease 
      Díaz, Paula; Sandoval Bórquez, Alejandra María Loreto; Bravo Sagua, Roberto Francisco; Quest, Andrew Frederick Geoffery; Lavandero González, Sergio Alejandro (Frontiers Media, 2021)
      In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although ...