Browsing by Subject "Polymorphisms"

Now showing items 1-19 of 19

    • Arsenic exposure, profiles of urinary arsenic species, and polymorphism effects of glutathione-s-transferase ... 
      González-Martínez, Farith; Sánchez-Rodas, Daniel; Cáceres, Dante D.; Martínez, Matías F.; Quiñones Sepúlveda, Luis; Johnson-Restrepo, Boris (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd This study assessed the effects of polymorphic variants of gutathione-S-transferase and metallothioneins on profiles of urinary arsenic species. Drinking groundwater from Margarita and San Fernando, ...
    • Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review 
      Arancibia, Trinidad; Morales Pisón, Sebastián; Maldonado Maldonado, Edio Luis; Jara Sosa, Lilian Elena (Sociedad de Biología de Chile, 2021)
      Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...
    • Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR- 196a2, Pre-miR-423, miR-608 and ... 
      Morales, Sebastián; Gulppi, Felipe; González Hormazábal, Patricio; Fernández Ramires, Ricardo; Bravo, Teresa; Reyes, José; Poblete Gómez, Fernando Andrés; Waugh, Enrique; Jara Sosa, Lilian (BioMed Central, 2016)
      Background: MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide polymorphisms (SNP) ...
    • Association study among candidate genetic polymorphisms and chemotherapy-related severe toxicity in testicular ... 
      Lavanderos, María A.; Cayún, Juan P.; Roco, Ángela; Sandoval, Christopher; Cerpa, Leslie; Rubilar, Juan C.; Cerro, Roberto; Molina-Mellico, Sebastián; Celedón, Cesar; Cerda, Berta; García-Martín, Elena; Agúndez, José A.G.; Acevedo, Cristián; Peña, Karina; Cáceres, Dant (Frontiers Media S.A., 2019)
      Testicular cancer is one of the most commonly occurring malignant tumors in young men with fourfold higher rate of incidence and threefold higher mortality rates in Chile than the average global rates. Surgery is the initial ...
    • CAG repeat polymorphism of androgen receptor gene and X-chromosome inactivation in daughters of women with ... 
      Echiburú López, Bárbara; Pérez Bravo, Francisco; Maliqueo Yevilao, Manuel; Ladrón de Guevara, Amanda; Gálvez, Carla; Crisosto King, Nicolás; Sir Petermann, Teresa (2012)
      Background: The polycystic ovary syndrome (PCOS) is a hyperandrogenic disorder that arise from a combination of genetic and environmental factors. Aim: To assess the role of the androgen receptor (AR) CAG repeat polymorphism ...
    • Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy? 
      Roco, ángela; Cayún, Juan; Contreras, Stephania; Stojanova, Jana; Quiñones, Luis (Frontiers Media S.A., 2014)
      © 2014 Roco, Cayún, Contreras, Stojanova and Quiñones.Several recent pharmacogenetic studies have investigated the variability in both outcome and toxicity in cisplatin-based therapies. These studies have focused on the ...
    • Effect of CYP3A4, CYP3A5, MDR1 and POR genetic polymorphisms in immunosuppressive treatment in chilean ... 
      Contreras Castillo, Stephania Nichols; Plaza, Anita; Stojanova, Jana; Navarro, Gustavo; Carmona, Rodolfo; Corvalán, Fernando; Cerpa, Leslie; Sandoval, Christopher; Muñoz, Daniel; Leiva, Marina; Castañeda Sepúlveda, Luis Eduardo; Farías, Nayaret; Álvarez, Carolina; Llull Morchio, Gabriel Eduardo; Mezzano, Sergio; Ardiles, Leopoldo; Varela Figueroa, Nelson Miguel; Rodríguez, María S.; Flores, Claudio; Cayún, Juan Pablo; Krall Opazo, Paola Margarita; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and ...
    • Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica 
      Quiñones Sepúlveda, Luis; Roco Arriagada, Ángela; Cayún Pellizaris, Juan; Escalante, Paula; Miranda Melo, Carla; Varela Figueroa, Nelson; Meneses, Francisca; Gallegos, Bastián; Zaruma Torres, Fausto; Lares Asseff, Ismael (Sociedad Médica de Santiago, 2017)
      Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, ...
    • Functionally significant coumarin-related variant alleles and time to therapeutic range in chilean ... 
      Rojo, Mario; Roco Arriagada, Ángela; Suárez, Marcelo; Lavanderos Villagrán, María Alejandra; Verón, Gabriel; Bertoglia Arredondo, María Paz; Arredondo, Annabella; Nieto, Elena; Rubilar, Juan Carlos; Tamayo, Francisca; Cruz, Daniela; Muñóz, Jessica; Bravo, Gabriela; Salas, Patricio; Mejías, Fanny; Véliz, Paulo; Godoy, Gerald; Varela Figueroa, Nelson; Llull, G.; Quiñones Sepúlveda, Luis (SAGE, 2020)
      Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide. In Chile, the Ministry of ...
    • Gene frequencies for four hypervariable DNA loci in a Chilean population of mixed ancestry 
      Acuña, M.; Jorquera, H.; Armanet Bernales, Leonor; Cifuentes Ovalle, Lucía (2000)
    • Genetic variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 are associated ... 
      Morales, Sebastián; De Mayo, Tomas; Gulppi, Felipe Andrés; González Hormazábal, Patricio; Carrasco, Valentina; Reyes, José Miguel; Gómez, Fernando; Waugh, Enrique; Jara, Lilian (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC ...
    • Host associated polymorphisms in the Corynebacterium pseudotuberculosis rpoB gene sequence 
      Retamal Merino, Patricio; Ríos Canales, Marco; Cheuquepán Valenzuela, Felipe; Abalos Pineda, Pedro; Pizarro Lucero, José; Borie Polanco, Consuelo; Gutiérrez Domínguez, Josefina (2011)
      Corynebacterium pseudotuberculosis is a widespread facultative intracellular pathogen that causes caseous lymphadenitis disease in sheep and goats, and generates cutaneous abscesses and granulomas in horses and cattle. ...
    • IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients 
      González Hormazábal, Patricio; Romero, Sandra; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, Victor Gonzalo; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2018)
      © 2018 International Institute of Anticancer Research. All rights reserved. Background/Aim: Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis ...
    • Impact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival 
      Acevedo, Cristián A.; Quiñones, Luis A.; Catalán, Johanna; Cáceres, Dante D.; Fullá, Juan A.; Roco, Angela M. (Elsevier Inc., 2014)
      Objective: Prognostic biomarkers that distinguish between patients with good or poor outcome can be used to guide decisions of whom to treat and how aggressively. In this sense, several groups have proposed genetic ...
    • Interferon lambda 4 rs12979860 C>T polymorphism is not associated with liver fibrosis in patients with ... 
      Brahm Barril, Javier; Urzúa Manchego, Álvaro; Poniachik Teller, Jaime; Cáceres, Dante D.; Carreño, Laura; Luca Venegas, Mauricio Pascual de (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between ...
    • Polymorphisms in mitochondrial genes encoding complex i subunits are maternal factors of voluntary alcohol ... 
      Sapag, Amalia; González Martínez, Ginez Andrés; Lobos González, Lorena; Encina, Gonzalo; Tampier de Jong, Lutske; Israel Jacard, Yedy; Quintanilla González, María Elena (2009)
      OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The ...
    • Relation of genetic variants of CYP2A6 with tobacco dependence and smoking habit in Chilean subjects. A ... 
      Lillo Cáceres, Dante D.; Alvarado, Sergio A.; Martínez, Paulina; Quiñones, Luis A. (2012)
      Background: Genetic and metabolic factors associated with nicotine metabolism may be related to smoking behavior. Aim: To assess the prevalence of allelic and genotype variants of CYP2A6 in a sample of Chilean subjects and ...
    • Role of cytokine gene polymorphisms in gastric cancer risk in Chile 
      González Hormazábal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Escandar, Susana; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, V. Gonzalo; Rubio-Reyes, Cristian; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2014)
      Aim: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility. Patients and Methods: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1β-IL1B-, IL8, IL17A, IL17F, ...
    • Serotype-associated polymorphisms in a partial rpoB gene sequence of Salmonella enterica 
      Fresno, Marcela; Barreto, Marlen; Gutierrez, Sindy; Dougnac, Catherine; Abalos, Pedro; Retamal Merino, Patricio (2014)
      Salmonella enterica is a zoonotic bacterium with more than 2500 serotypes, which affect a wide range of hosts and produce diverse clinical outcomes. Strain identification usually involves costly and time-demanding procedures. ...