Browsing by Subject "RAB11 Trafficking"

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    • The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells 
      Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...