Browsing by Subject "Vaccine"

Now showing items 1-20 of 23

    • A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells ... 
      Gleisner Muñoz, María Alejandra; Pereda Ramos, Cristián; Tittarelli Elaskar, Andrés; Navarrete Sánchez, Mariela; Fuentes Villegas, Camila; Ávalos, Ignacio; Tempio Sepúlveda, Fabián; Araya, Juan Pablo; Becker, María Inés; González Bergas, Fermín; López Nitsche, Mercedes; Salazar Onfray, Flavio (BMJ, 2020)
      Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of ...
    • Chitosan-based nanoparticles for Intracellular delivery of ISAV fusion protein cDNA into melanoma cells: a ... 
      Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)
      Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
    • Effectiveness of a proteoliposome‑based vaccine against salmonid rickettsial septicaemia in Oncorhynchus mykiss 
      Caruffo Olmeño, Mario Antonio Jorge; Vidal, Sonia; Santis, Leonardo; Siel Martínez, Daniela; Pérez, Oliver; Huenchullanca Castillo, Paula Beatriz; Sáenz, Leonardo (BMC, 2021)
      Salmonid rickettsial septicaemia (SRS) is a contagious disease caused by Piscirickettsia salmonis, an intracellular bacterium. SRS causes an estimated economic loss of $700 million USD to the Chilean industry annually. ...
    • Effectiveness of an immunocastration vaccine formulation to reduce the gonadal function in female and male ... 
      Siel Siel, Daniela; Vidal Vilches, Sonia; Sevilla Reyes, Rafael; Paredes, Rodolfo; Carvallo, Francisco; Lapierre Acevedo, Lisette; Maino Menéndez, Mario; Pérez, Oliver; Sáenz Iturriaga, Leonardo Enrique (Elsevier, 2016)
      Immunocastration has emerged as an alternative to surgical castration in different animal species. This study examined the effectiveness of a new vaccine formulation for immunocastration using the biopolymer chitosan as ...
    • Efficacy, immunogenicity, and safety of a 9-valent human papillomavirus vaccine in latin american girls, ... 
      Ruiz Sternberg, Angela María; Moreira, Edson D.; Restrepo, Jaime A.; Lazcano Ponce, Eduardo; Cabello, Robinson; Silva, Arnaldo; Andrade, Rosires; Revollo, Francisco; Uscanga, Santos; Victoria, Alejandro; Guevara, Ana María; Luna, Joaquín; Plata, Manuel; Nossa Dominguez, Claudia; Fedrizzi, Edison; Suárez, Eugenio; Reina, Julio C.; Ellison, Misoo C.; Moeller, Erin; Ritter, Michael; Shields, Christine; Cashat, Miguel; Perez, Gonzalo; Luxembourg, Alain (Elsevier, 2018-06)
      Background: A 9-valent human papillomavirus (HPV6/11/16/18/31/33/45/52/58; 9vHPV) vaccine was developed to expand coverage of the previously developed quadrivalent (HPV6/11/16/18; qHPV) vaccine. Methods: Efficacy, ...
    • Encapsulation of cochleates derived from salmonella infantis with biopolymers to develop a potential oral ... 
      Avendaño, Constanza; Vidal, Sonia; Villamizar Sarmiento, María Gabriela; Guzmán, Miguel; Hidalgo Olate, Hector Anibal; Lapierre Acevedo, Lisette Nicole; Valenzuela Venegas, Carolina Paz; Sáenz Iturriaga, Leonardo Enrique (MDPI, 2021)
      The aim of this study was to develop and characterize Salmonella enterica serovar Infantis (S. Infantis) cochleates protected by encapsulation technology as a potential vaccine and to determine its safety in pullets. ...
    • Enzymatic protein biopolymers as a tool to synthetize eukaryotic messenger Ribonucleic Acid (mRNA) with ... 
      Urbina Donoso, Fabiola; Morales Pison, Sebastián; Maldonado Maldonado, Edio (MDPI, 2020)
      Multi-subunit enzymes are protein biopolymers that are involved in many cellular processes. The enzyme that carries out the process of transcription of mRNAs is RNA polymerase II (RNAPII), which is a multi-subunit enzyme ...
    • From a pathogen’s genome to an effective vaccine: The four-component meningococcal serogroup b vaccine Del ... 
      Abad, Raquel; Martinón-Torres, Federico; Santolaya de Pablo, María Elena; Banzhoff, Angelika; González-Inchausti, Carmen; Graña, Maria Gabriela; Vázquez, Julio A. (Sociedad Espanola de Quiminoterapia, 2019)
      © 2019, Sociedad Espanola de Quiminoterapia. All rights reserved.Invasive meningococcal disease (IMD), caused by the bacterium Neisseria meningitidis, entails significant mortality and morbidity. Disease incidence is highest ...
    • Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in ... 
      Weitzel, Thomas; Rodríguez, Fernanda; Noriega, Luis Miguel; Marcotti, Alejandra; Durán, Luisa; Palavecino Oñate, Carla; Porte, Lorena; Aguilera, Ximena; Wolff Reyes, Marcelo; Cortés Moncada, Claudia (Public Library Science, 2020)
      Background Coinfections of HIV patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) are mayor public health problems, contributing to the emerging burden of HIV-associated hepatic mortality. Coinfection ...
    • Human papillomavirus vaccine. Statement of the Consultive Committee of Immunizations on behalf of The Chilean ... 
      Abarca Villaseca, Katia; Valenzuela Bravo, María Teresa; Vergara F., Rodrigo; Luchsinger Farías, Vivian; Muñoz M., Alma; Jiménez de la Jara, Jorge; Ripoll M., Erna; O'Ryan Gallardo, Miguel (2008)
      The article briefly reviews the epidemiology of human papillomavirus (HPV) infection and associated diseases in the world and in Chile and the scientific information of the licensed HPV vaccines: Gardasil® and Cervarix®. ...
    • Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal ... 
      Montero Forero, David; Canto Fuentes, Felipe del; Salazar Garrido, Juan Carlos; Céspedes Ulloa, Sandra; Cádiz Núñez, Leandro; Arenas Salinas, Mauricio; Reyes, José; Oñate, Ángel; Vidal Álvarez, Roberto (Nature, 2020)
      Shiga toxin-producing Escherichia coli (STEC) cause diarrhea and dysentery, which may progress to hemolytic uremic syndrome (HUS). Vaccination has been proposed as a preventive approach against STEC infection; however, ...
    • Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine in elderly residents of a long-term care facility 
      Valenzuela, M. Teresa B.; Altuzarra, Rogelio H.; Trucco, Olivia A.; Villegas, Rodrigo R.; Inostroza, Jaime S.; Granata, Paulo S.; Fleiderman, José V.; Maggi, Leonardo C. (2007)
      S. pneumoniae is a significant cause of community-acquired pneumonia in the elderly, and accounts for the majority of the pneumonia deaths among the elderly. We conducted this randomized double-blind study to evaluate the ...
    • Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples 
      Alemany, L.; Saunier, M.; Tinoco, L.; Quirós, B.; Alvarado Cabrero, I.; Alejo, M.; Joura, E. A.; Maldonado, P.; Klaustermeier, J.; Salmerón, J.; Bergeron, C.; Petry, K. U.; Guimerà, N.; Clavero, O.; Murillo, R.; Clavel, C.; Wain, V.; Geraets, D. T.; Jach, R.; Cross, P.; Carrilho, C.; Molina, C.; Shin, H. R.; Mandys, V.; Nowakowski, A. M.; Vidal, A.; Lombardi, L.; Kitchener, H.; Sica, A. R.; Magaña León, C.; Pawlita, M.; Quint, W.; Bravo, I. G.; Muñoz, N.; Sanjosé, S. de; Bosch, F. X. (Elsevier, 2014)
      Aim: This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. Methods: We analysed ...
    • New insights for vaccine development against Clostridium difficile infections 
      Pizarro-Guajardo, Marjorie; Chamorro Veloso, Nayaret; Vidal, Roberto Mauricio; Paredes Sabja, Daniel (Academic Press, 2019)
      Increased antibiotic usage is the main risk factor for gut microbiota dysbiosis. In dysbiosis, there is an increased susceptibility to intestinal pathogens, such as Clostridium difficile infection, the leading cause of ...
    • Norovirus vaccines under development 
      Lucero, Yalda; Vidal, Roberto; O'Ryan Gallardo, Miguel (Elsevier Ltd, 2018)
      © 2017 Elsevier Ltd Noroviruses (NoVs) are one of the leading causes of acute gastroenteritis, including both outbreaks and endemic infections. The development of preventive strategies, including vaccines, for the most ...
    • Norovirus: facts and reflections from past, present, and future 
      Lucero Álvarez, Yalda; Matson, David O.; Ashkenazi, Shai; George Carreño, Sergio Andrés; O'Ryan Gallardo, Miguel (MDPI, 2021)
      Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and ...
    • Persistence of antibodies in adolescents 18-24 months after immunization with one, two, or three doses of ... 
      Santolaya de Pablo, María Elena; O'Ryan Gallardo, Miguel; Valenzuela, María Teresa; Prado Jiménez, Valeria; Vergara, Rodrigo F.; Muñoz, Alma; Toneatto, Daniela; Graña, Gabriela; Wang, Huajun; Dull, Peter M. (Taylor & Francis, 2013)
      We previously demonstrated the immunogenicity and tolerability of the serogroup B meningococcal vaccine, 4CMenB (Bexsero®), in 11-17 y-olds randomized to receive 1, 2, or 3 doses at 1, 2, or 6 mo intervals. participants ...
    • Reproductive and behavioral evaluation of a new immunocastration dog vaccine 
      Siel, Daniela; Ubilla, María José; Vidal Vilches, Sonia; Loaiza Farias, Alexandra; Quiroga Ardiles, John; Cifuentes Ramos, Federico; Hardman, Timothy; Lapierre Acevedo, Lisette; Paredes, Rodolfo; Sáenz Iturriaga, Leonardo (MDPI, 2020)
      Simple Summary Population control of free-roaming dogs is a topic of great interest worldwide. Immunocastration (immune blockade of GnRH-I, the hormone that commands reproductive ability) has emerged as a complementary ...
    • Role of Human Papillomavirus in Penile Carcinomas Worldwide 
      Alemany, Laia; Cubilla, Antonio; Halec, Gordana; Kasamatsu, Elena; Quiros, Beatriz; Masferrer, Emili; Tous, Sara; Lloveras, Belén; Hernández Suárez, Gustavo; Lonsdale, Ray; Tinoco, Leopoldo; Alejo, María; Alvarado Cabrero, Isabel; Laco, Jan; Guimera, Nuria; Poblet, Enrique; Lombardi, Luis E.; Bergeron, Christine; Clavero, Omar; Shin, Hai-Rim; Ferrera, Annabelle; Félix, Ana; Germar, Julieta; Mandys, Vaclav; Clavel, Christine; Tzardi, María; Pons, Luis E.; Wain, Vincent; Cruz, Eugenia; Molina, Carla; Mota, José D.; Jach, Robert; Velasco, Julio; Carrilho, Carla; López Revilla, Rubén; Goodman, Marc T.; Quint, Wim G.; Castellsague, Xavier; Bravo, Ignacio; Pawlita, Michael; Muñoz, Nubia; Bosch, F. Xavier; de Sanjose, Silvia (Elsevier, 2016)
      Background: Invasive penile cancer is a rare disease with an approximately 22 000 cases per year. The incidence is higher in less developed countries, where penile cancer can account for up to 10% of cancers among men in ...
    • Rotavirus genotypes in children with gastroenteritis assisted in two public hospitals from Chile: Viral ... 
      Lucero, Yalda; Mamani, Nora; Orellana Cortés, Héctor Hernán; Peña, Alfredo; Vergara, Rodrigo C.; Gallardo, Miguel O.Ryan (2012)
      Background: Rotavirus is the main cause of severe gastroenteritis (GE) in children. Two vaccines currently available have proven effi cacy against the predominant genotypes. Rotavirus genotypes vary both geographically ...