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El Profesor Doctor Hernán Alessandri: su legado para las nuevas generaciones de médicos
(Sociedad Médica de Santiago, 2015)
109
HISTORIA DE LA MEDICINA
Rev Med Chile 2015; 143: 109-111
El Profesor Doctor Hernán Alessandri:
su legado para las nuevas generaciones
de médicos
SebaStian roSSon M.
Professor Hernán Alessandri, M.D.:
his legacy...
-111) Key words: Chile; Education, medical; Famous persons; History of Medicine, 20th Century. Residente becario de Medicina Interna, Departamento de Medicina (Campus Oriente), Facultad de Medicina, Universidad de Chile y Servicio de Medicina del...
-111) Key words: Chile; Education, medical; Famous persons; History of Medicine, 20th Century. Residente becario de Medicina Interna, Departamento de Medicina (Campus Oriente), Facultad de Medicina, Universidad de Chile y Servicio de Medicina del...
Historia de la anatomía en Chile Parte II. El Alma Mater
(Sociedad Chilena de Anatomía Patológica (SCHAP), 2020)
extrauniversitaria, pasan a enseñar en 1978 desde la Real Universidad de San Felipe, al Instituto Nacional en 1833 y de éste, a la actual
Universidad de Chile, en 1842. Siguiendo los preceptos de las Primas de Medicina españolas, el desarrollo de la disciplina se...
medicina se realiza- ba según la usanza española, siguiendo las indicaciones de la Pragmática, cátedra prima de Medicina (Rabí, 2006) donde todos los contenidos eran desarrollados por un profesor tal como se hacía en otros países de nuestra américa y con...
medicina se realiza- ba según la usanza española, siguiendo las indicaciones de la Pragmática, cátedra prima de Medicina (Rabí, 2006) donde todos los contenidos eran desarrollados por un profesor tal como se hacía en otros países de nuestra américa y con...
Ideación suicida en escolares de 10 a 13 años, de ambos sexos, de colegios de la comuna de Viña del Mar: factores sociodemográficos, psicológicos y familiares asociados
(Universidad de Chile, 2015)
La presente investigación pretende aportar conocimientos respecto de la ideación suicida en preadolescentes y los factores sociodemográficos, psicológicos y familiares asociados. Metodología: Estudio transversal, de carácter descriptivo...
Infección por Tripanosoma cruzi en grupos familiares y perros de viviendas positivas al vector Triatoma infestans: Calera de Tango y Til Til, Región Metropolitana
(Universidad de Chile, 2008)
rurales de Calera de Tango y Til Til, la presencia reiterada de ejemplares adultos de este insecto. Por ello, esta investigación planteó como objetivo principal pesquisar infección chagásica en los integrantes de estos grupos familiares y sus perros...
Demandas y necesidades en salud de la población aymara en tres comunas de la provincia de Iquique
(Universidad de Chile, 2008)
medicina indígena y/o popular
que los entrevistados o familiares han acudido a componedores, santiguadores,
machis, yerbateros y parteras. La principal razón por la que acuden a estos
agentes es de origen mágico-religioso (Sáez, M. 2003).
31
También...
Universidad de Chile Facultad de Medicina Escuela de Salud Pública “Demandas y Necesidades en Salud de la Población Aymara en tres Comunas de...
Universidad de Chile Facultad de Medicina Escuela de Salud Pública “Demandas y Necesidades en Salud de la Población Aymara en tres Comunas de...
Estudio de Validación de un Cuestionario para evaluar Calidad de Vida Universitaria en los Estudiantes de la Facultad de Medicina de la Universidad de Chile
(Universidad de Chile, 2013-05)
En el marco del modelo de Universidad Saludable propuesto por la Organización Mundial de la Salud, orientado a promover la salud y el bienestar, y mejorar la calidad de vida de sus estudiantes, un equipo de investigadores de la Facultad de Medicina...
Forma familiar de la enfermedad de Creutzfeldt-Jakob: marcadores genéticos en 4 familias chilenas
(2006)
1116
A R T Í C U L O D E
I N V E S T I G A C I Ó N
Forma familiar de la enfermedad
de Creutzfeldt-Jakob: marcadores
genéticos en 4 familias chilenas
Luis Cartier R1, Jorge Fernández O2, Eugenio Ramírez V3,4.
Genetic...
) Recibido el 30 de octubre, 2005. Aceptado el 17 de marzo, 2006. 1Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Hospital del Salvador, Santiago, Chile. 2Sección de Biología Molecular y 3Departamento de Virología...
) Recibido el 30 de octubre, 2005. Aceptado el 17 de marzo, 2006. 1Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Hospital del Salvador, Santiago, Chile. 2Sección de Biología Molecular y 3Departamento de Virología...
Variantes de baja penetrancia de los genes FGFR2 y MAP3K1 y su asociación con el riesgo para cancer de mama en población chilena
(Universidad de Chile, 2012)
.
Actualmente, en Chile y en otras poblaciones Sudamericanas no existen estudios
que relacionen los loci de susceptibilidad de baja penetrancia con aumento del riesgo
a CM familiar. La realización de estos estudios ayudaría a comprender las bases
genéticas de la...
Breast cancer (BC) is one of the major health problems of woman worldwide. Risk factors attributable to the development of disease include: age, ethnicity, hormonal exposure and genetic factors, being the latter the most important. Current model pro posed to explain genetic susceptibility to BC is the polygenic one, and includes the involvement of high, moderate and low-penetrance genes. Low- penetrance genes FGFR2 and MAP3K1 presented the highest associations with increased risk of BC. FGFR2 gene encodes growth factor receptor and MAP3K1 gene encodes serine/ threonine kinase, member of mitogen activated kinases (MAPK). The event down stream of FGFR2 activation pathway includes the MAPK pathway. In addition of their individual effect, is postulated that the interaction between both genes may increase the risk of BC. Recently, many studies have been conducted in women from European, Asian and African origin in which differences in risk estimates to BC could be attributable to dif ferences in genetic structure. Currently in Chile and other South American populations, there are not studies ana lyzing low-pentrance BC genes with increase risk of familial BC. The completion of these studies could help to understand the genetic basis of susceptibility of BC in this population. The present thesis studied the association with BC risk of low - penetrance variants rs1219648, rs2981582 and rs2420946 (FGFR2 gene) and rs889312 (MAP3K1 gene), and the interaction between both genes. A case- control study was performed in 307 cases of familial BC BRCA1/2 negative and 614 healthy controls without familial BC history. Genotyping was performed using 5'Exonuclease Taqman® assay. The re sults showed that the risk allele frequencies of FGFR2 variants were higher in cases (values between 0.48 and 0.49 for the three SNPs of FGFR2 gene) compared to con trols (value of 0.40 for the three SNPs). The FGFR2 gene variants were associated with increased risk of BC in homozygous for the risk allele (rs1219648 GG OR= 1.83[CI 95% 1.2 – 2.8]; rs2981582 TT OR= 1.91[CI95% 1.3 – 2.9]; rs2420946 TT OR= 2.03[CI95% 1.3 – 3.1]) for the complete sample. After stratification by family history, the highest associations were for the risk homozygous of SNP's rs1219648 and rs2420946 (OR= 2.15 [CI95% 1.1 – 4.1] and OR= 2.27 [CI95% 1.2 – 4.2], re spectively) in BC cases without family history diagnosed at age ≤50 years. For SNP rs889312 (MAP3K1 gene), results showed that risk allele was higher in cas es (0.45) compared with controls (0.36) of entire sample. Also, after stratification by family history, the highest association was for the risk homozygote CC (OR= 2.40 [CI95% 1.3 – 4.4]) in BC cases without family history diagnosed at age ≤50 years. Finalized, we analyzed the combined genotypes between FGFR2 gene variants rs1219648, rs2981582, rs2420946 and MAP3K1 rs889312. The most significant dif ferences were observed in BC cases without family history diagnosed at age ≤50 year, where the double risk homozygote for variants rs1219648 and rs889312 showed the highest association (OR= 5.63[CI95% 1.9 – 17.0]). Combined genotypes that included the risk homozygote for variant rs889312 (MAP3K1 gene) showed in creased risk of BC; hence, this genotype by itself increases the risk of BC, unlike the risk homozygous for any of FGFR2 gene variants analyzed that were not significantly increased the risk of BC. These results suggest that SNPs of the FGFR2 gene acts by enhancing the effect of SNP rs889312 MAP3K1 gene....
Breast cancer (BC) is one of the major health problems of woman worldwide. Risk factors attributable to the development of disease include: age, ethnicity, hormonal exposure and genetic factors, being the latter the most important. Current model pro posed to explain genetic susceptibility to BC is the polygenic one, and includes the involvement of high, moderate and low-penetrance genes. Low- penetrance genes FGFR2 and MAP3K1 presented the highest associations with increased risk of BC. FGFR2 gene encodes growth factor receptor and MAP3K1 gene encodes serine/ threonine kinase, member of mitogen activated kinases (MAPK). The event down stream of FGFR2 activation pathway includes the MAPK pathway. In addition of their individual effect, is postulated that the interaction between both genes may increase the risk of BC. Recently, many studies have been conducted in women from European, Asian and African origin in which differences in risk estimates to BC could be attributable to dif ferences in genetic structure. Currently in Chile and other South American populations, there are not studies ana lyzing low-pentrance BC genes with increase risk of familial BC. The completion of these studies could help to understand the genetic basis of susceptibility of BC in this population. The present thesis studied the association with BC risk of low - penetrance variants rs1219648, rs2981582 and rs2420946 (FGFR2 gene) and rs889312 (MAP3K1 gene), and the interaction between both genes. A case- control study was performed in 307 cases of familial BC BRCA1/2 negative and 614 healthy controls without familial BC history. Genotyping was performed using 5'Exonuclease Taqman® assay. The re sults showed that the risk allele frequencies of FGFR2 variants were higher in cases (values between 0.48 and 0.49 for the three SNPs of FGFR2 gene) compared to con trols (value of 0.40 for the three SNPs). The FGFR2 gene variants were associated with increased risk of BC in homozygous for the risk allele (rs1219648 GG OR= 1.83[CI 95% 1.2 – 2.8]; rs2981582 TT OR= 1.91[CI95% 1.3 – 2.9]; rs2420946 TT OR= 2.03[CI95% 1.3 – 3.1]) for the complete sample. After stratification by family history, the highest associations were for the risk homozygous of SNP's rs1219648 and rs2420946 (OR= 2.15 [CI95% 1.1 – 4.1] and OR= 2.27 [CI95% 1.2 – 4.2], re spectively) in BC cases without family history diagnosed at age ≤50 years. For SNP rs889312 (MAP3K1 gene), results showed that risk allele was higher in cas es (0.45) compared with controls (0.36) of entire sample. Also, after stratification by family history, the highest association was for the risk homozygote CC (OR= 2.40 [CI95% 1.3 – 4.4]) in BC cases without family history diagnosed at age ≤50 years. Finalized, we analyzed the combined genotypes between FGFR2 gene variants rs1219648, rs2981582, rs2420946 and MAP3K1 rs889312. The most significant dif ferences were observed in BC cases without family history diagnosed at age ≤50 year, where the double risk homozygote for variants rs1219648 and rs889312 showed the highest association (OR= 5.63[CI95% 1.9 – 17.0]). Combined genotypes that included the risk homozygote for variant rs889312 (MAP3K1 gene) showed in creased risk of BC; hence, this genotype by itself increases the risk of BC, unlike the risk homozygous for any of FGFR2 gene variants analyzed that were not significantly increased the risk of BC. These results suggest that SNPs of the FGFR2 gene acts by enhancing the effect of SNP rs889312 MAP3K1 gene....
Satisfacción con la atención médica de pacientes hospitalizados en un servicio clínico docente y en uno no docente
(Universidad de Chile, 2012)
uno no docente. Material y método: Estudio de corte transversal. Se aplicó un cuestionario para evaluar satisfacción con la atención médica y grado de aceptación hacia estudiantes de Medicina, a pacientes hospitalizados en servicios de urología del...
Impacto del ejercicio de fuerza muscular en la prevención secundaria de la obesidad infantil: intervención al interior del sistema escolar
(Universidad de Chile, 2012)
a su contextura y condición física, ejercicios personalizados, identificación asociativa con los pares, entorno familiar y social de apoyo, acercamiento a la sensación de satisfacción por la disminución de peso. Entre las barreras, resaltaron, la...