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Incorporación de médicos especialistas a la atención primaria ¿una paradoja nacional?
(SOC MEDICA SANTIAGO, 2008-08)
autoridad sanitaria, que es parte de la
Reforma, establece diversas medidas para au-
mentar la tecnología de los consultorios de APS1.
3. Refuerzo con médicos de familia. La medicina
familiar ha adquirido especial desarrollo, en
particular en atención a los...
1997; 125: 796-807. 11. Sociedad Científica de Medicina Familiar y General de Chile. La medicina familiar en la reforma de salud chilena. Rev Ch Med Familiar 2000; 1: 25-32. 12. IPINZA M. Cómo solucionar el déficit de médicos en los consultorios urbanos...
1997; 125: 796-807. 11. Sociedad Científica de Medicina Familiar y General de Chile. La medicina familiar en la reforma de salud chilena. Rev Ch Med Familiar 2000; 1: 25-32. 12. IPINZA M. Cómo solucionar el déficit de médicos en los consultorios urbanos...
Asociación entre variación germinal en mirnas y susceptibilidad al cáncer de mama familiar en población chilena y su rol en la transformación celular
(Universidad de Chile, 2021)
responsables en promedio de un 16-
20% del riesgo para CM familiar. Se ha propuesto que otros alelos de susceptibilidad denominados de moderada y baja penetrancia podrían ser responsables del 80% restante de los casos
de CM familiar BRCA1/2-negativo. Evidencia...
In Chile, breast cancer (BC) has the highest cancer mortality rate in women (16.6/100,000 women). The main risk factor for BC development is genetic predisposition. Mutations in the BRCA1/2 genes are responsible for 40–50% of familial BC risk on average. It has been proposed that other so-called moderate- and low-penetrance susceptibility alleles could be responsible for the remaining 50% of BRCA1/2-negative familial BC cases. Recent evidence suggests that microRNAs (miRNAs) are candidate low-penetrance genes for BC susceptibility. Various studies have shown that miRNAs are aberrantly expressed in cancer and that the presence of genetic variants in the pre-miRNA or mature miRNA sequence could be the cause of their dysregulation. Given the above, this study assessed the association of SNP rs4541843, located in the pri-miR-182, with risk of familial BC using a case-control design. Furthermore, BC cell lines were used to evaluate the functional roles of SNPs rs6505162 (pre-miR-423), rs895819 (pre-miR-27a), and rs4541843 in mammary tumorigenesis. The association results showed that the rs4541843 T allele was linked to increased risk of developing BC in BRCA1/2-negative Chilean patients. This is the first study to evaluate an association between rs4541843 and any human pathology. A previous study determined that the rs6505162 A allele increased BC risk in a Chilean population and that the rs895819 G allele had a protective effect, reducing the risk of developing BC. Here, the functional study based on this concept showed that the rs6505162 A allele increased cell proliferation, migration, and invasion. In addition, the A allele promoted resistance to cisplatin and decreases apoptosis, confirming its role as a risk allele. On the other hand, the rs895819 G allele was found to function differentially in mammary tumorigenic processes depending on BC subtype, participating as a tumor suppressor in the triple-negative BC subtype but as an oncogene in the luminal A subtype. Finally, it was observed that the rs4541843 C allele had an oncogenic role, increasing cell proliferation, migration, and invasion, as well as promoting resistance to cisplatin and decreasing apoptosis. These results indicate that the risk allele was the C allele, not the T allele. These findings are the first to characterize the functional role of SNPs rs6505162, rs895819, and rs4541843 in mammary tumorigenesis....
In Chile, breast cancer (BC) has the highest cancer mortality rate in women (16.6/100,000 women). The main risk factor for BC development is genetic predisposition. Mutations in the BRCA1/2 genes are responsible for 40–50% of familial BC risk on average. It has been proposed that other so-called moderate- and low-penetrance susceptibility alleles could be responsible for the remaining 50% of BRCA1/2-negative familial BC cases. Recent evidence suggests that microRNAs (miRNAs) are candidate low-penetrance genes for BC susceptibility. Various studies have shown that miRNAs are aberrantly expressed in cancer and that the presence of genetic variants in the pre-miRNA or mature miRNA sequence could be the cause of their dysregulation. Given the above, this study assessed the association of SNP rs4541843, located in the pri-miR-182, with risk of familial BC using a case-control design. Furthermore, BC cell lines were used to evaluate the functional roles of SNPs rs6505162 (pre-miR-423), rs895819 (pre-miR-27a), and rs4541843 in mammary tumorigenesis. The association results showed that the rs4541843 T allele was linked to increased risk of developing BC in BRCA1/2-negative Chilean patients. This is the first study to evaluate an association between rs4541843 and any human pathology. A previous study determined that the rs6505162 A allele increased BC risk in a Chilean population and that the rs895819 G allele had a protective effect, reducing the risk of developing BC. Here, the functional study based on this concept showed that the rs6505162 A allele increased cell proliferation, migration, and invasion. In addition, the A allele promoted resistance to cisplatin and decreases apoptosis, confirming its role as a risk allele. On the other hand, the rs895819 G allele was found to function differentially in mammary tumorigenic processes depending on BC subtype, participating as a tumor suppressor in the triple-negative BC subtype but as an oncogene in the luminal A subtype. Finally, it was observed that the rs4541843 C allele had an oncogenic role, increasing cell proliferation, migration, and invasion, as well as promoting resistance to cisplatin and decreasing apoptosis. These results indicate that the risk allele was the C allele, not the T allele. These findings are the first to characterize the functional role of SNPs rs6505162, rs895819, and rs4541843 in mammary tumorigenesis....
Usos de tecnologías sanitarias de envejecidos de la cuarta edad en el Programa Nacional de Salud del Adulto Mayor
(Universidad de Chile, 2018-11)
tecnologías sanitarias de los envejecidos. ............................. 38
a. Resistencias y autodisciplinamientos. ............................................................. 38
b. Palabras y conceptos de la medicina usados por los envejecidos...
con medicina no sanitaria. .......... 64 VII. Reflexiones en torno a los usos de tecnologías sanitarias............................. 70 VIII. Conclusiones...
con medicina no sanitaria. .......... 64 VII. Reflexiones en torno a los usos de tecnologías sanitarias............................. 70 VIII. Conclusiones...
Transformaciones en el modelo familiar aceptación, acogida y reconocimiento de la situación transgénero
(Universidad de Chile, 2013-03)
la diversificación de las formas familiares en el contexto sociocultural Latinoamericano, el ideal de familia chileno continúa siendo el modelo de familia tradicional nuclear biparental compuesto por padre, madre e hijos(as), el cual responde al...
Percepción y valoración de los funcionarios de la Facultad de Medicina en relación a las prácticas y políticas de conciliación trabajo-familia en su institución
(Universidad de Chile, 2013-05)
En un mundo globalizado como en el de hoy, hemos experimentado diversos cambios sociales. En particular, la interacción entre la esfera laboral y familiar -ámbitos fundamentales en la vida de las personas- ha sufrido cambios drásticos...
LA MEDICINA ANTROPOLÓGICA Y EL JUICIO DE NÜRENBERG. El aporte de Viktor von Weizsäcker
(Centro Interdisciplinario de Estudios en Bioética - Universidad de Chile, 2010-11)
Monografías de ACTA BIOETHICA
(ISSN 0717-5906) Nº 5 - 2010
LA MEDICINA ANTROPOLÓGICA Y EL JUICIO DE NÜRENBERG. El aporte de
Viktor von Weizsäcker
© CIEB
Primera edición, noviembre de 2010
Registro de Propiedad...
. Monografías de ACTA BIOETHICA Nº 5 - 2010 Centro Interdisciplinario de Estudios en Bioética - Universidad de Chile LA MEDICINA ANTROPOLÓGICA Y EL JUICIO DE NÜRENBERG El aporte de Viktor von Weizsäcker Fernando Lolas Stepke Índice Autores 7 Preámbulo 9 PARTE...
. Monografías de ACTA BIOETHICA Nº 5 - 2010 Centro Interdisciplinario de Estudios en Bioética - Universidad de Chile LA MEDICINA ANTROPOLÓGICA Y EL JUICIO DE NÜRENBERG El aporte de Viktor von Weizsäcker Fernando Lolas Stepke Índice Autores 7 Preámbulo 9 PARTE...
Calidad de vida y funcionamiento familiar en adolescentes con depresión en centros de salud pública
(Universidad de Chile, 2013)
Esta investigación se centró en determinar la relación entre las dimensiones de Calidad de Vida Relacionada con la Salud (CVRS) y el Estilo de Funcionamiento Familiar en adolescentes entre 15 y 18 años, de ambos sexos, con diagnóstico de Depresión...
Abstención terapéutica
(1995)
ser tomadas con consulta a los comites y la familia, que en ultimo termino representa a los intereses del paciente. El servicio de la medicina a la vida no implica prolongarla a toda costa y circunstancia, sino considerando su calidad y procurando el...
Lenguaje grafico y textual para la evaluación neurokinesica de pacientes con accidente vascular encefálico, ensayo aleatorio tipo "CROSSOVER"
(Universidad de Chile, 2017)
médica se han estudiado y comparado interfaces escritas y gráficas. Una propuesta gráfica es el lenguaje icónico “Visualización de Conceptos en Medicina” (VCM/Mister) utilizado para representar conceptos médicos, situaciones clínicas, síntomas, riesgos y...
BACKGROUND: The challenge in developing computational interfaces for clinical decision making is to facilitate user - computer interaction. In order to improve the presentation of data and facilitate the management of medical information, written and graphical interfaces have been studied and compared. A graphic proposal is the iconic language "Visualization of Concepts in Medicine" (VCM/Mister) used to represent medical concepts, clinical situations, symptoms, risks and morbidities, treatments, procedures, among other medical concepts. The present study considers comparing the difference in Response Error and Time used to respond, as opposed to exposure to clinical data related to Stroke expressed in both VCM/Mister graphical interface and in writing. METHODS: An experimental, random cross-over design was applied in which 10 physical therapists were randomly exposed to 10 clinical cases related to Stroke expressed in both written and graphical language. Each case was associated with a question with a dichotomous answer. The time used to respond and the proportion of response error were measured. For statistical analysis in the case of time the non-parametric test of Mann Whitney was applied, and for the error response ratio the MacNemar Chi-square test. RESULTS: In this study, the analysis of the variables used with a significance level of 0.05 did not show statistically significant differences for the Response Time (p-value = 0.3067) and for the Response Error (p-value = 1) exposure to clinical data expressed both in VCM/Mister graphical interface and in writing....
BACKGROUND: The challenge in developing computational interfaces for clinical decision making is to facilitate user - computer interaction. In order to improve the presentation of data and facilitate the management of medical information, written and graphical interfaces have been studied and compared. A graphic proposal is the iconic language "Visualization of Concepts in Medicine" (VCM/Mister) used to represent medical concepts, clinical situations, symptoms, risks and morbidities, treatments, procedures, among other medical concepts. The present study considers comparing the difference in Response Error and Time used to respond, as opposed to exposure to clinical data related to Stroke expressed in both VCM/Mister graphical interface and in writing. METHODS: An experimental, random cross-over design was applied in which 10 physical therapists were randomly exposed to 10 clinical cases related to Stroke expressed in both written and graphical language. Each case was associated with a question with a dichotomous answer. The time used to respond and the proportion of response error were measured. For statistical analysis in the case of time the non-parametric test of Mann Whitney was applied, and for the error response ratio the MacNemar Chi-square test. RESULTS: In this study, the analysis of the variables used with a significance level of 0.05 did not show statistically significant differences for the Response Time (p-value = 0.3067) and for the Response Error (p-value = 1) exposure to clinical data expressed both in VCM/Mister graphical interface and in writing....
Rendimiento Académico en estudiantes de la carrera de Medicina Veterinaria cohorte 2001
(Universidad de Chile, 2012)
, pertenecientes a la carrera de Medicina Veterinaria de la Universidad de Chile, a través de distintas variables ligadas a este. Además, se determinó la probabilidad de éxito académico, entendido como la obtención del título de Médico Veterinario, en función de...