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The potential role of protein kinase R as a regulator of age-related neurodegeneration
(Frontiers Media, 2021)
that allows cell adaptation is the integrated stress response (ISR), which senses
stress stimuli through four kinases. ISR activation promotes translational arrest through
the phosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2a...
Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease
(MDPI, 2020)
. Nevertheless, the role of the integrated stress response (ISR) involving UPRmt and mitophagy in the development and progression of these illnesses is still a matter of debate, considering that some studies indicate that the prolonged exposure to low levels...
Vertigo and dizziness in the elderly
(Frontiers Media, 2015)