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Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
(Oxford University Press, 2017-06)
stress response’ (ISR) (Pakos-
Zebrucka et al., 2016).
Phosphorylation of eIF2a also allows
the translation of certain mRNAs con-
taining short open reading frames in
the 5’-untranslated region, leading to
expression of activating transcription
factor 4...
). These biological activities are shared with other kinases of the ISR pathway, as reported in functional studies aimed at manipulating PKR and GCN2 in the context of synaptic plasticity and Alzheimer’s disease. Recent drug dis- covery efforts to target the PERK/ e...
). These biological activities are shared with other kinases of the ISR pathway, as reported in functional studies aimed at manipulating PKR and GCN2 in the context of synaptic plasticity and Alzheimer’s disease. Recent drug dis- covery efforts to target the PERK/ e...
(off) Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor & Francis, 2018)
known as the integrated stress response (ISR) [4].
Increased levels of phosphorylated PERK and eIF2α have been
found in postmortem brain tissue of patients affected with several
neurodegenerative diseases including Alzheimer’s and Parkinson’s
disease...
. In models of multiple sclerosis and spinal cord injury, PERK/eIF2α signaling is pro- posed to attenuate symptoms and improve oligodendrocyte function. Overall, accumulating studies suggests that pharma- cological targeting of PERK signaling and the ISR may...
. In models of multiple sclerosis and spinal cord injury, PERK/eIF2α signaling is pro- posed to attenuate symptoms and improve oligodendrocyte function. Overall, accumulating studies suggests that pharma- cological targeting of PERK signaling and the ISR may...
Mastering organismal aging through the endoplasmic reticulum proteostasis network
(Wiley, 2020)
and may
also involve the ISR (Denzel et al., 2014; Horn et al., 2020). In addi-
tion, recent evidence suggests that the cell-surface hyaluronidase
TMEM2, which modulates the composition of the extracellular ma-
trix, also regulates lifespan...
Proteostasis disturbance in amyotrophic lateral sclerosis
(Oxford University Press, 2017)
.
ER-associated protein degradation (ERAD): designates a cellular pathway that targets misfolded proteins from the ER to ubiq-
uitination and subsequent degradation in the cytosol by the proteasome.
Integrated stress response (ISR): It is a eukaryotic...