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The potential role of protein kinase R as a regulator of age-related neurodegeneration
(Frontiers Media, 2021)
that allows cell adaptation is the integrated stress response (ISR), which senses
stress stimuli through four kinases. ISR activation promotes translational arrest through
the phosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2a...
Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease
(MDPI, 2020)
. Nevertheless, the role of the integrated stress response (ISR) involving UPRmt and mitophagy in the development and progression of these illnesses is still a matter of debate, considering that some studies indicate that the prolonged exposure to low levels...
Vertigo and dizziness in the elderly
(Frontiers Media, 2015)
emergency rooms? Isr Med Assoc J (2012) 14:633–6.
13. Saber Tehrani AS, Kattah JC, Mantokoudis G, Pula JH, Nair D, Blitz A,
et al. Small strokes causing severe vertigo: frequency of false-negative MRIs
and nonlacunar mechanisms. Neurology (2014) 83...
Mastering organismal aging through the endoplasmic reticulum proteostasis network
(Wiley, 2020)
and may
also involve the ISR (Denzel et al., 2014; Horn et al., 2020). In addi-
tion, recent evidence suggests that the cell-surface hyaluronidase
TMEM2, which modulates the composition of the extracellular ma-
trix, also regulates lifespan...