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(off) Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor & Francis, 2018)
known as the integrated stress response (ISR) [4].
Increased levels of phosphorylated PERK and eIF2α have been
found in postmortem brain tissue of patients affected with several
neurodegenerative diseases including Alzheimer’s and Parkinson’s
disease...
. In models of multiple sclerosis and spinal cord injury, PERK/eIF2α signaling is pro- posed to attenuate symptoms and improve oligodendrocyte function. Overall, accumulating studies suggests that pharma- cological targeting of PERK signaling and the ISR may...
. In models of multiple sclerosis and spinal cord injury, PERK/eIF2α signaling is pro- posed to attenuate symptoms and improve oligodendrocyte function. Overall, accumulating studies suggests that pharma- cological targeting of PERK signaling and the ISR may...
Mastering organismal aging through the endoplasmic reticulum proteostasis network
(Wiley, 2020)
and may
also involve the ISR (Denzel et al., 2014; Horn et al., 2020). In addi-
tion, recent evidence suggests that the cell-surface hyaluronidase
TMEM2, which modulates the composition of the extracellular ma-
trix, also regulates lifespan...
Proteostasis disturbance in amyotrophic lateral sclerosis
(Oxford University Press, 2017)
.
ER-associated protein degradation (ERAD): designates a cellular pathway that targets misfolded proteins from the ER to ubiq-
uitination and subsequent degradation in the cytosol by the proteasome.
Integrated stress response (ISR): It is a eukaryotic...