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Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype
(EXCERPTA MEDICA INC, 2003-09-15)
actions of angiotensin-(1-7) depend on an intracellular
signaling mechanism, as yet not fully characterized,
that may be caused by secretion of prostacyclin, re-
lease of nitric oxide, amplification of the vasodilator
effects of bradykinin, or vasopressin...
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
(Amer Biochemistry Molecular Biology, 2004-02-27)
under “Experimental Procedures.” Values
represent the average of three different experiments� S.D. **, p� 0.01
and *, p � 0.05 versus time 0 min.
IP3-dependent Calcium Increase by IGF-1
lease, inhibited IGF-1-induced Ca2� transients in cardiomyo-
cytes...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
(ENDOCRINE SOC, 2010-10)
� by itself triggers translocation/
fusion of GLUT4 with the plasma
membrane, the IP3R-dependent re-
lease participate in specific pathways
aimed to that purpose.
Finally, the involvement of �� sub-
units of a heterotrimeric G protein in
GLUT4 translocation...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
(ENDOCRINE SOC, 2006-03)
testosterone and nandrolone produce
rapid intracellular Ca2� transients (16) involving Ca2� re-
lease from inositol 1,4,5-trisphosphate (IP3)-sensitive stores
(22). This rapid Ca2� transient was not modified by cypro-
terone, an inhibitor of steroid binding...
Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
(Elsevier, 2020)
, thus increasing the complexity of Ca2 + signaling. Ba-
sically, Ca2 + waves are one of the most sophisticated codes within the
cell and are subordinated to specific mechanisms controlling Ca2 + re-
lease and SR Ca2 + homeostasis in time and space...
- leased from SR/ER stores accumulates in a confined space, forming a microdomain of high Ca2 + concentration. Nonetheless, certain stimuli (such as membrane depolarization in myocytes) can evoke Ca2 + release events strong enough to activate adjacent...
- leased from SR/ER stores accumulates in a confined space, forming a microdomain of high Ca2 + concentration. Nonetheless, certain stimuli (such as membrane depolarization in myocytes) can evoke Ca2 + release events strong enough to activate adjacent...
Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis
(Elsevier, 2018)
counteracts mutant alpha-synu-
clein-induced ER stress via the homeostatic regulation of ER-resident calcium re-
lease channel proteins, Hum. Mol. Genet. 21 (2012) 963–977.
[7] S.L. Chan, W. Fu, P. Zhang, A. Cheng, J. Lee, K. Kokame, M.P. Mattson, Herp sta...