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Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex
(2008)
on endoplasmic reticulum (ER) Ca 2� re-
lease have received less attention (Herna´ndez-Fonseca and
Massieu, 2005). The ER has an important role as a regulator of
intracellular [Ca 2�] in neurons (Berridge et al., 1998; Pape et
al., 2004; Verkhratsky, 2005...
12 binding to type 1 calcium re- lease channels. Antioxid Redox Signal 7:870 – 881. Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL (2006) Identification of cysteines involved in S-nitrosylation, S...
12 binding to type 1 calcium re- lease channels. Antioxid Redox Signal 7:870 – 881. Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL (2006) Identification of cysteines involved in S-nitrosylation, S...
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
(Elsevier, 2014)
with
glutaredoxin fully reversed Ca2+ release to the control condition
(Fig. 8B). Incubation with NADPH plus GSH did not enhance Ca2+ re-
lease in SR vesicles incubated with 50 μM ryanodine for 30 min before
the release measurement, indicating that the increased Ca2...
at the single channel level, and b) increased Ca2+ re- lease rates measured in isolated SR vesicles. The enhanced response of single RyR2 channels to cytoplasmic [Ca2+], induced ex vivo by I5R1 or in vitro by activation of NOX2, was reversed by DTT...
at the single channel level, and b) increased Ca2+ re- lease rates measured in isolated SR vesicles. The enhanced response of single RyR2 channels to cytoplasmic [Ca2+], induced ex vivo by I5R1 or in vitro by activation of NOX2, was reversed by DTT...
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
(Elsevier, 2020)
prevented sIR-induced necrosis (Fig. 4B).
These results show that Mfn2 is directly involved in cardiomyocyte
protection during IR, with an efficacy that depends on concentration.
Moreover, NRVMs knocked down to Mfn2 showed increased LDH re-
lease in baseline...
Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning?
(ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003-12)
+ when mixed with the re-
leasing solution that maximally stimulated Ca2+ release,
without significant differences between the experimental
groups (data not shown). This release of Ca2+ was inhibited
by ruthenium red, a specific inhibitor of RyR2/Ca2...
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-31)
different responses. Glutathi-
one disulfide significantly reduces the inhibitory effect
of Mg2� without altering Ca2� activation of release ki-
netics, whereas NOR-3 enhances Ca2� activation of re-
lease kinetics without altering Mg2� inhibition. Incuba...