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Intracellular Ca2+ transients induced by high external K+ and tetracaine in cultured rat myotubes
(1994)
to high [Ktlo with a
mhmte Ca2+ signal and responded toother Ca2’ re-
lease drugs including caffeine (10 rnM) in a more
substantial manner.
To evaluate in a quantitative manner the effects
of different experimental parameters, such as Ca2’
360...
’ represents he ‘effective valence’ of the voltage sensor esponsible for the coupling between the membrane potential Vm and the fast Ca’+ re- lease process; V0 is the midpoint potential and [Ca2+]p”(V, = 20 mV) is the maximal Ca2+ con- centration...
’ represents he ‘effective valence’ of the voltage sensor esponsible for the coupling between the membrane potential Vm and the fast Ca’+ re- lease process; V0 is the midpoint potential and [Ca2+]p”(V, = 20 mV) is the maximal Ca2+ con- centration...
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
(Amer Biochemistry Molecular Biology, 2004-02-27)
under “Experimental Procedures.” Values
represent the average of three different experiments� S.D. **, p� 0.01
and *, p � 0.05 versus time 0 min.
IP3-dependent Calcium Increase by IGF-1
lease, inhibited IGF-1-induced Ca2� transients in cardiomyo-
cytes...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
Differences in both inositol 1,4,5-trisphosphate mass and inositol 1,4,5-trisphosphate receptors between normal and dystrophic skeletal muscle cell lines
(John Wiley, 1998)
+-channels and causes Ca2+ re-
lease from intracellular Ca2+ stores.3 However, the
role of this mechanism in the fast calcium transients
needed for twitch skeletal muscle excitation–
contraction coupling remains controversial.18 We
have proposed a role...
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
(Biomed Central, 2016)
skeletal primary cultures and adult fibers
[19, 20]. Our studies place extracellular ATP as a master
regulator of the E-T coupling leading to muscle plasticity
(as reviewed in [21]). We demonstrated that ATP is re-
leased by physiological activity...
[20]. We can conclude that the re- leased ATP and its metabolites are fundamental mediators between electrical stimulation, slow intracellular calcium transients, and gene expression related to muscle plasticity [19]. Taken all the previous work...
[20]. We can conclude that the re- leased ATP and its metabolites are fundamental mediators between electrical stimulation, slow intracellular calcium transients, and gene expression related to muscle plasticity [19]. Taken all the previous work...
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
(ENDOCRINE SOC, 2010-10)
� by itself triggers translocation/
fusion of GLUT4 with the plasma
membrane, the IP3R-dependent re-
lease participate in specific pathways
aimed to that purpose.
Finally, the involvement of �� sub-
units of a heterotrimeric G protein in
GLUT4 translocation...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
(ENDOCRINE SOC, 2006-03)
testosterone and nandrolone produce
rapid intracellular Ca2� transients (16) involving Ca2� re-
lease from inositol 1,4,5-trisphosphate (IP3)-sensitive stores
(22). This rapid Ca2� transient was not modified by cypro-
terone, an inhibitor of steroid binding...
Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis
(Elsevier, 2018)
counteracts mutant alpha-synu-
clein-induced ER stress via the homeostatic regulation of ER-resident calcium re-
lease channel proteins, Hum. Mol. Genet. 21 (2012) 963–977.
[7] S.L. Chan, W. Fu, P. Zhang, A. Cheng, J. Lee, K. Kokame, M.P. Mattson, Herp sta...
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kg-Akt-AS160 in Skeletal Muscle Cells
(American Diabetes Association, 2013)
ryanodine-sensitive stores, whereas the slow component is
Ca2+ released through inositol-1,4,5-trisphosphate receptor
(IP3R) (21,23) and depends on ATP concomitantly re-
leased from the stimulated cells (24). ATP signals in skel-
etal muscle through P2Y...
Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells
(ELSEVIER SCIENCE BV, 2005-04-11)
potent blocker of the endoplasmic-reticulum calcium
pump [14]. However, subsequent studies were unable to ob-
serve any inhibitory effect of XeC on caffeine-induced Ca2+ re-
lease, suggesting that the calcium pump was unaffected by the
alkaloid [36...