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Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype
(EXCERPTA MEDICA INC, 2003-09-15)
actions of angiotensin-(1-7) depend on an intracellular
signaling mechanism, as yet not fully characterized,
that may be caused by secretion of prostacyclin, re-
lease of nitric oxide, amplification of the vasodilator
effects of bradykinin, or vasopressin...
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
(Amer Biochemistry Molecular Biology, 2004-02-27)
under “Experimental Procedures.” Values
represent the average of three different experiments� S.D. **, p� 0.01
and *, p � 0.05 versus time 0 min.
IP3-dependent Calcium Increase by IGF-1
lease, inhibited IGF-1-induced Ca2� transients in cardiomyo-
cytes...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
in cardiac myocytes; re- lease at the nuclear level is independent of both external cal- cium and ryanodine receptors. At the cytosolic level, on the other hand, a fast component of the calcium transient appears to be regulated by the presence of external...
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
(ENDOCRINE SOC, 2010-10)
� by itself triggers translocation/
fusion of GLUT4 with the plasma
membrane, the IP3R-dependent re-
lease participate in specific pathways
aimed to that purpose.
Finally, the involvement of �� sub-
units of a heterotrimeric G protein in
GLUT4 translocation...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
that a link exists between IP3R-dependent Ca 2� re- lease and GLUT4 translocation, but this mechanism is particular for certain stimuli. In particular, the link between IP3R-dependent Ca 2� release andmobilizationofGLUT4 is a novel contribution...
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
(ENDOCRINE SOC, 2006-03)
testosterone and nandrolone produce
rapid intracellular Ca2� transients (16) involving Ca2� re-
lease from inositol 1,4,5-trisphosphate (IP3)-sensitive stores
(22). This rapid Ca2� transient was not modified by cypro-
terone, an inhibitor of steroid binding...
Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
(Elsevier, 2020)
, thus increasing the complexity of Ca2 + signaling. Ba-
sically, Ca2 + waves are one of the most sophisticated codes within the
cell and are subordinated to specific mechanisms controlling Ca2 + re-
lease and SR Ca2 + homeostasis in time and space...
- leased from SR/ER stores accumulates in a confined space, forming a microdomain of high Ca2 + concentration. Nonetheless, certain stimuli (such as membrane depolarization in myocytes) can evoke Ca2 + release events strong enough to activate adjacent...
- leased from SR/ER stores accumulates in a confined space, forming a microdomain of high Ca2 + concentration. Nonetheless, certain stimuli (such as membrane depolarization in myocytes) can evoke Ca2 + release events strong enough to activate adjacent...
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
(Elsevier, 2020)
prevented sIR-induced necrosis (Fig. 4B).
These results show that Mfn2 is directly involved in cardiomyocyte
protection during IR, with an efficacy that depends on concentration.
Moreover, NRVMs knocked down to Mfn2 showed increased LDH re-
lease in baseline...
TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
(2013)
into the
extracellular medium; whereas reperfusion produced a significant re-
lease of LDH into the extracellularmedium (see Supplementary Fig. 2B).
CA
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38 KDa
57 KDa
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f via
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Grap
756 R. Vivar et al. / Biochimica et Biophysica Acta...
Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis
(Elsevier, 2018)
counteracts mutant alpha-synu-
clein-induced ER stress via the homeostatic regulation of ER-resident calcium re-
lease channel proteins, Hum. Mol. Genet. 21 (2012) 963–977.
[7] S.L. Chan, W. Fu, P. Zhang, A. Cheng, J. Lee, K. Kokame, M.P. Mattson, Herp sta...
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kg-Akt-AS160 in Skeletal Muscle Cells
(American Diabetes Association, 2013)
ryanodine-sensitive stores, whereas the slow component is
Ca2+ released through inositol-1,4,5-trisphosphate receptor
(IP3R) (21,23) and depends on ATP concomitantly re-
leased from the stimulated cells (24). ATP signals in skel-
etal muscle through P2Y...
Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells
(PERGAMON-ELSEVIER SCIENCE LTD, 2004-05)
. Observations in patients with
severe alcoholic cirrhosis display increases in soluble plasma
TNF-R1 (sTNF-R1) levels (Naveau et al., 1998), likely re-
leased from cell membranes by proteolytic cleavage of
TNF-R1 (Jurewicz et al., 1999).Two groups...