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Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors
(Public Library Science, 2015)
, where addition of exogenous
H2O2 promotes RyR redox modifications and specifically stimulates RyR-mediated Ca
2+ re-
lease [30, 59].
Additionally, we found that 100 μMH2O2 disrupted GSIS, confirming previous reports in
rat islets [29] and mouse...