Browsing by Title Facultad de Medicina

Now showing items 10622-10641 of 12961

    • Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells 
      Kohan Ivani, Karla; Gabler Neale, Fernando; Selman,; Vega Blanco, María Margarita; Romero Osses, Carmen (Springer Verlag, 2016)
      © 2015, The Author(s).Purpose: One of the hypotheses regarding the genesis of epithelial ovarian cancer involves the action of androgens on the proliferation of epithelial ovarian cells, as well as inclusion cysts. The ...
    • Role of endogenous opioids in the cardiovascular responses to asphyxia in fetal sheep 
      Espinoza,; Riquelme,; Germain,; Tevah,; Parer,; Llanos, (1989)
      Intravenous administration of the opioid receptor antagonist naloxone to asphyxiated fetal sheep increases the arterial blood pressure. We examined the hypothesis that endogenous opioids modify the cardiac output distribution ...
    • Role of epitranscriptomic and epigenetic modifications during the lytic and latent phases of herpesvirus infections 
      Soto, Abel A.; Ortiz, Gerardo; Contreras, Sofía; Soto Rifo, Ricardo Andrés; González, Pablo A. (MDPI, 2022)
      Herpesviruses are double-stranded DNA viruses occurring at a high prevalence in the human population and are responsible for a wide array of clinical manifestations and diseases, from mild to severe. These viruses are ...
    • Role of epstein-barr virus and human papillomavirus coinfection in cervical cancer: Epidemiology, Mechanisms ... 
      Blanco, Rances; Carrillo Beltrán, Diego; Osorio, Julio C.; Calaf, Gloria M.; Aguayo González, Francisco (MDPI, 2020)
      High-risk human papillomavirus (HR-HPV) is etiologically associated with the development and progression of cervical cancer, although other factors are involved. Epstein-Barr virus (EBV) detection in premalignant and ...
    • Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1 
      Vivar Sánchez, Raúl; Humeres, Claudio; Anfossi, Renatto; Bolívar, Samir; Catalán Díaz, Mabel; Hill, Joseph; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2020)
      Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
    • Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1 
      Carrasco Mujica, Loreto; Cea, Paola; Rocco, Paola; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Sotomayor Flores, Cristian Alejandro; Quiroga, Clara; Criollo Céspedes, Alfredo; Ibarra, Cristián; Chiong Lay, Mario; Lavandero González, Sergio (Wiley-Liss, 2014)
      In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
    • Role of Human Papillomavirus in Penile Carcinomas Worldwide 
      Alemany, Laia; Cubilla, Antonio; Halec, Gordana; Kasamatsu, Elena; Quiros, Beatriz; Masferrer, Emili; Tous, Sara; Lloveras, Belén; Hernández Suárez, Gustavo; Lonsdale, Ray; Tinoco, Leopoldo; Alejo, María; Alvarado Cabrero, Isabel; Laco, Jan; Guimera, Nuria; Poblet, Enrique; Lombardi, Luis E.; Bergeron, Christine; Clavero, Omar; Shin, Hai-Rim; Ferrera, Annabelle; Félix, Ana; Germar, Julieta; Mandys, Vaclav; Clavel, Christine; Tzardi, María; Pons, Luis E.; Wain, Vincent; Cruz, Eugenia; Molina, Carla; Mota, José D.; Jach, Robert; Velasco, Julio; Carrilho, Carla; López Revilla, Rubén; Goodman, Marc T.; Quint, Wim G.; Castellsague, Xavier; Bravo, Ignacio; Pawlita, Michael; Muñoz, Nubia; Bosch, F. Xavier; de Sanjose, Silvia (Elsevier, 2016)
      Background: Invasive penile cancer is a rare disease with an approximately 22 000 cases per year. The incidence is higher in less developed countries, where penile cancer can account for up to 10% of cancers among men in ...
    • Role of KCTD5 during Helicobacter pylori infection in gastric epithelial cells 
      Toledo Araya, Héctor; Alvarez A., José Miguel; Uribe, F.; Canales, J.; Canto, N.; Cerda Arancibia, Óscar (Wiley, 2017)
    • Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi 
      Castillo, C.; López-Muñoz, R.; Duaso, J.; Galanti Garrone, Norbel; Jaña, F.; Ferreira, J.; Cabrera, G.; Maya Arango, Juan; Kemmerling Weis, Ulrike (2012)
      Background: Chagas' disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier. In the present study we analyzed the ...
    • Role of microRNA-23b in epithelial ovarian cancer and its regulation by nerve growth factor 
      Romero Osses, Carmen; Hernández, Andrea; Cuevas, Paula; Retamales, Rocio; Vera, Carolina; Vega Blanco, María Margarita (Spandidos Publications Ltd., 2017)
    • Role of mir-92a-3p in the expression of genes ofchemoresistance to fluorouracil and oxaliplatin viaactivation ... 
      Escalante Escalante, Paula Isabel (Universidad de Chile, 2022)
      El cáncer colorrectal (CCR) es el segundo más diagnosticado en Chile y el mundo. El tratamiento de primera línea del CCR metastásico consiste en la asociación de 5-fluorouracilo (5-FU) y oxaliplatino (L-OHP), conocido ...
    • Role of MNS1 in cilia motility during zebrafish development 
      Pulgar Pulgar, Eduardo; Concha Nordemann, Miguel (Elsevier, 2017-07)
    • Role of nerve growth factor (NGF) and miRNAs in epithelial ovarian cancer 
      Retamales-Ortega, Rocío; Oróstica Arévalo, María Lorena; Vera, Carolina; Cuevas, Paula; Hernández, Andrea; Hurtado, Iván; Vega Blanco, María Margarita; Romero Osses, Carmen (MDPI AG, 2017)
      © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Ovarian cancer is the eighth most common cancer in women worldwide, and epithelial ovarian cancer (EOC) represents 90% of cases. Nerve growth factor (NGF) and its ...
    • Role of Neutralizing Antibodies in Adults With Community-Acquired Pneumonia by Respiratory Syncytial Virus 
      Luchsinger Farías, Vivian; Piedra, Pedro A.; Ruiz, Mauricio; Zunino, Enna; Martínez, María Angélica; Machado, Clarisse; Fasce, Rodrigo; Ulloa Flores, María Teresa; Fink, María Cristina; Lara, Pamela; Avendaño, Luis F. (2012-04)
      Background. Respiratory syncytial virus (RSV) has been implicated in the etiology of adult communityacquired pneumonia (CAP). We investigated RSV infection in Chilean adults with CAP using direct viral detection, real-time ...
    • Role of nitric oxide and bcl-2 family genes in the regulation of human endometrial apoptosis 
      Castro, Andrea; Johnson, María Cecilia; Anido, Mabel; Cortinez, Armando; Gabler Neale, Fernando; Vega Blanco, María Margarita (2002)
      Objective: To investigate the role of nitric oxide (NO) and death regulatory genes, bcl-2 and bax, in human endometria apoptosis.Design: Expression of bcl-2, bax, NO synthases (NOS), and the apoptotic effect of L-arginine ...
    • Role of oxidative stress in renal transplantation: bases for an n-3 PUFA strategy against delayed graft function 
      Sotomayor, Camilo; Cortes, Ignacio A.; Gormaz, Juan G.; Vera, Sergio; Libuy, Matías; Valls Jiménez, Nicolás; Rodrigo Salinas, Ramón (Bentham Science Publ Ltd., 2017)
      Renal transplantation (RT) is considered the "gold standard" treatment for end-stage renal disease patients. Efforts should be made to reduce ischaemia-reperfusion (IR) injury, which unavoidably occurs in RT as long as ...
    • Role of oxidative stress in the mechanisms of anthracyclineInduced cardiotoxicity: effects of preventive strategies 
      Carrasco, Rodrigo; Castillo Peñaloza, Rodrigo Luis; Gormaz Araya, Juan Guillermo; Carrillo, Montserrat; Thavendiranathan, Paaladinesh (Hindawi, 2021)
      Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. ...
    • Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase ... 
      Rossello, Xavier; Riquelme, Jaime A.; Davidson, Sean M.; Yellon, Derek M. (Wiley, 2018)
      The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
    • Role of pirin, an oxidative stress sensor protein, in epithelial carcinogenesis 
      Pérez Domínguez, Francisco Javier; Carrillo Beltrán, Diego Antonio; Blanco Santana, Rancés; Muñoz, Juan P.; León Cruz, Grettell; Corvalán, Alejandro H.; Urzúa Tobar, Ulises de la Cruz; Calaf, Gloria M.; Aguayo, Francisco (MDPI, 2021)
      Simple Summary Pirin is a protein which is detected at low levels in normal tissues. However, it is detected at high levels in multiple cancers, particularly in melanomas, cervical cancer or squamous cell lung carcinomas. ...
    • Role of placental barrier integrity in infection by Trypanosoma cruzi 
      Díaz Luján, C.; Triquell, M. F.; Castillo Varela, Christian; Hardisson, D.; Kemmerling Weis, Ulrike; Fretes, R. E. (Elsevier, 2016)
      American trypanosomiasis has long been a neglected disease endemic in LatinAmerica, but congenital transmission has now spread Chagas disease to cause a global health problem. As the early stages of the infection of placental ...