Browsing by Title Facultad de Medicina
Now showing items 10642-10661 of 12946
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(WILEY-BLACKWELL, 2012-01)Synaptic function is crucially dependent on the spatial organization of the presynaptic and postsynaptic apparatuses and the juxtaposition of both membrane compartments. This precise arrangement is achieved by a protein ...
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(Society of Biology of Chile, 2005)The specific signaling connections between the mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK-1) and phosphatases PP4 and M3/6, affecting the family of early nuclear factors, is complex and ...
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Role of the Planar Cell Polarity Pathway in the Morphogenesis of the Laterality Organ in Zebrafish (Universidad de Chile, 2009)A pesar de su aparente simetría bilateral, el plan corporal de los vertebrados presenta consitentes asimetrías en localización, estructura y función de diversos órganos internos como el corazón, los intestinos y el cerebro. ...
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(Frontiers Media, 2022)Advances in our understanding of cancer biology have contributed to generating different treatments to improve the survival of cancer patients. However, although initially most of the therapies are effective, relapse and ...
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(1971)Acute infusions of angiotensin II or dog renin into hypophysectomized nephrectomized dogs has no effect on the conversion of corticosterone to aldosterone. This conversion was measured in an isolated mitochondrial fraction ...
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Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs (Amer Physiological Soc, 2016)Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, ...
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(Wiley, 2017)BackgroundIntrathecal/intracisternal BDNF in rodents produces long-lasting hyperalgesia/allodynia, which implies BDNF plays a role in the establishment and maintenance of central sensitization. Both self-regeneration of ...
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(BioScientifica Ltd., 2010)Fifty to seventy percent of patients with polycystic ovary syndrome (PCOS) present hyperinsulinemia. On the other hand, reports indicate that forkhead box class O 1 (FOXO1) and peroxisome proliferator-activated receptor-g ...
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(2013)The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding and maturation of around one-third of the total proteome. Accumulation of misfolded proteins in the ER lumen engages a signal transduction ...
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(2011)Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
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(SOC BIOLGIA CHILE, 2006)Thyroid hormone (TH; 3,3,,5-triiodothyronine, T-3) is required for the normal function of most tissues, with major effects on O-2 consumption and metabolic rate. These are due to transcriptional activation of respiratory ...
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(Universidad de la Frontera, 2016)© 2016, Universidad de la Frontera. All rights reserved. Sonic hedgehog (SHH) is an essential morphogen for the development of neural tube, members and somites. Variations in expression can cause abnormalities in the nervous ...
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(HINDAWI PUBLISHING CORPORATION, 2006)Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies. This brain disorder is characterized by the formation of brain protein aggregates, namely, ...
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(Elsevier, 2014)One of the properties of bacteria is their capacity to acquire large fragments of genomic DNA from other bacteria or to loose important parts of their own genome. Such fragments include genomic islands (GIs); nine GIs ...
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(2012)The genomic island 3 (GI-3) shared by Brucella melitensis and Brucella abortus contains 29 genes encoding mostly unknown proteins. Within this island, the open reading frames (ORFs) BAB1_0278 and BAB1_0263 are present, ...
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(2012)In Latin America, there are about 10-12 million people infected with Trypanosoma cruzi, the agent of Chagas' disease, one of the most important neglected tropical parasitism. Identification of molecular targets, specific ...
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(Cell Press, 2016)
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(Public Library Science, 2015)During exercise, skeletal muscle produces reactive oxygen species (ROS) via NADPH oxidase (NOX2) while inducing cellular adaptations associated with contractile activity. The signals involved in this mechanism are still a ...
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(Public Library of Science, 2015)© 2015 Díaz-Vegas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...