Now showing items 11569-11588 of 12946

    • Nassif, Melissa; Hetz Flores, Claudio (LANDES BIOSCIENCE, 2011-04)
    • Nassif, Melissa; Hetz Flores, Claudio (Taylor and Francis Inc., 2011)
      Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
    • Durán Aniotz, Claudia; Cornejo, Victor Hugo; Hetz Flores, Claudio (Oxford University Press, 2016)
    • Durán Aniotz, Claudia; Cornejo, Víctor Hugo; Hetz Flores, Claudio (Oxford University Press, 2016)
      This scientific commentary refers to 'Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse', by Peng et al. (doi:10.1093/brain/awv385).
    • Lillo Moya, José Ignacio; Rojas Solé, Catalina Andrea; Muñoz Salamanca, Diego Ignacio; Panieri, Emiliano; Saso, Luciano; Rodrigo Salinas, Ramón (MDPI, 2021)
      Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally, reoxygenation has been recognized as the treatment of ...
    • Miller, Russell A.; Shi, Yuji; Lu, Wenyun; Pirman, David A.; Jatkar, Aditi; Blatnik, Matthew; Wu, Hong; Cárdenas Matus, Julio; Wan, Min; Foskett, J. Kevin; Park, Junyoung O.; Zhang, Yiyi; Holland, William L.; Rabinowitz, Joshua D.; Birnbaum, Morris J. (Nature Publishing Group, 2018)
      Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic ...
    • Métifiot, Mathieu; León Decap, Oscar; Tarrago-Litvak, Laura; Litvak, Simon; Andréola, Marie-Line (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2005-10)
      Several in vitro strategies have been developed to selectively screen for nucleic acid sequences that bind to specific proteins. We previously used the SELEX procedure to search for aptamers against HIV-1 RNase H activity ...
    • Carreño, Leandro J.; Prados Rosales, Rafael; López, Mercedes; Baena, Andrés; González, Pablo A. (Hindawi Limited, 2017)
    • Ponnappa, Biddanda C.; Israel Jacard, Yedy (Frontiers in Bioscience, 2002)
      © 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
    • Valenzuela, Rodrigo; Ortiz, Macarena; Hernández-Rodas, María Catalina; Echeverría, Francisca; Videla, Luis A. (Bentham Science, 2020)
      Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...
    • Mercado, Gabriela; Castillo, Valentina; Soto, Paulina; López, Nélida; Axten, Jeffrey M.; Sardi, Sergio P.; Hoozemans, Jeroen J.M.; Hetz Flores, Claudio (Academic Press Inc., 2018)
      © 2018 Elsevier Inc. Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars ...
    • Videla, Luis A.; Valenzuela Baez, Rodrigo Wladimir (Ame Publ Co, 2021)
    • Pérez Jeldres, Tamara; Álvarez Lobos, Manuel; Rivera Nieves, Jesús (Adis, 2021)
      Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, ...
    • Flynn, Robyn; Chapman, Kevin; Iftinca, Mircea; Aboushousha, Reem; Varela Lekanda, Diego; Altier, Christophe (The American Society for Biochemistry and Molecular Biology, 2014)
      The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a polymodal channel activated by noxious ...
    • Rivas, Alexis; Vidal, René; Hetz Flores, Claudio (Taylor & Francis, 2015)
      Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) generates a stress condition that engages the unfolded protein response (UPR). The UPR is an adaptive reaction that aims to reestablish ...
    • Hetz Flores, Claudio; Chevet, Eric; Harding, Heather P. (Macmillan, 2013)
      Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a feature of specialized secretory cells and is also observed in many diseases, including cancer, diabetes, autoimmune conditions, ...
    • Campolina Silva, Gabriel; Werneck Gomes, Hipacia; Bruna T., María; Barata, María C.; Torres, María José; Contreras Muñoz, Héctor; Mahecha, Germana; Oliveira, Cleida (Elsevier, 2020)
      Aims: The purpose of this study was to describe a suitable experimental model for studying aging-related prostate disorders including cancer. Materials and methods: 12-month old Wistar rats were kept in control conditions ...
    • Jerbi, Karim; Ossandón, Tomás; Hamamé, Carlos M.; Senova, S.; Dalal, Sarang S.; Jung, Julien; Minotti, Lorella; Bertrand, Olivier; Berthoz, Alain; Kahane, Philippe; Lachaux, Jean Philippe (2009)
      Although non-invasive techniques provide functional activation maps at ever-growing spatiotemporal precision, invasive recordings offer a unique opportunity for direct investigations of the fine-scale properties of neural ...
    • Saldanha, P. H.; Nacrur, J. (1963)
    • Morales, Inelia; Jiménez, José M.; Mancilla, Marcela; Maccioni Baraona, Ricardo (IOS Press, 2013)
      Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...