Browsing by Title Facultad de Medicina
Now showing items 11569-11588 of 12947
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(Ivyspring International Publisher, 2020)Knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, supporting a selective therapy against different types of cancer. In ...
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(LANDES BIOSCIENCE, 2011-04)
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(Taylor and Francis Inc., 2011)Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
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(Oxford University Press, 2016)
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(Oxford University Press, 2016)This scientific commentary refers to 'Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse', by Peng et al. (doi:10.1093/brain/awv385).
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(MDPI, 2021)Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally, reoxygenation has been recognized as the treatment of ...
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(Nature Publishing Group, 2018)Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic ...
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(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2005-10)Several in vitro strategies have been developed to selectively screen for nucleic acid sequences that bind to specific proteins. We previously used the SELEX procedure to search for aptamers against HIV-1 RNase H activity ...
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(Hindawi Limited, 2017)
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(Frontiers in Bioscience, 2002)© 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
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(Bentham Science, 2020)Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...
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(Academic Press Inc., 2018)© 2018 Elsevier Inc. Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars ...
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(Ame Publ Co, 2021)
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Targeting sphingosine-1-phosphate signaling in immune-mediated diseases: beyond multiple sclerosis (Adis, 2021)Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, ...
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(The American Society for Biochemistry and Molecular Biology, 2014)The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a polymodal channel activated by noxious ...
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(Taylor & Francis, 2015)Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) generates a stress condition that engages the unfolded protein response (UPR). The UPR is an adaptive reaction that aims to reestablish ...
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(Macmillan, 2013)Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a feature of specialized secretory cells and is also observed in many diseases, including cancer, diabetes, autoimmune conditions, ...
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(Elsevier, 2020)Aims: The purpose of this study was to describe a suitable experimental model for studying aging-related prostate disorders including cancer. Materials and methods: 12-month old Wistar rats were kept in control conditions ...
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(2009)Although non-invasive techniques provide functional activation maps at ever-growing spatiotemporal precision, invasive recordings offer a unique opportunity for direct investigations of the fine-scale properties of neural ...
