Browsing by Title Facultad de Medicina

Now showing items 12390-12409 of 12947

    • TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway 
      Armisen Yáñez, Ricardo; Marcelain Cubillos, Katherine; Simon, Felipe; Tapia, Julio C.; Toro, Jessica; Quest, Andrew F. G.; Stutzin Schottlander, Andrés (2011)
      Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin ...
    • TRPM4 Expression during postnatal developmental of mouse CA1 pyramidal neurons 
      Riquelme, Denise; Cerda Arancibia, Oscar Alejandro; Leiva Salcedo, Elías (Frontiers Media, 2021)
      TRPM4 is a non-selective cation channel activated by intracellular calcium and permeable to monovalent cations. This channel participates in the control of neuronal firing, neuronal plasticity, and neuronal death. TRPM4 ...
    • TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility 
      Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...
    • TRPM4 regulates Akt/GSK3-b activity and enhances b-catenin signaling and cell proliferation in prostate ... 
      Sagredo, A.; Sagredo, Eduardo A.; Cappelli, Claudio; Baez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (John Wiley, 2018)
      Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...
    • TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)
      Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...
    • Truncating variants in UBAP1 associated with childhood-onset nonsyndromic hereditary spastic paraplegia 
      Gu, S; Chen, CA; Rosenfeld, JA; Cope, H; Launay, N; Flanigan, KM; Waldrop, MA; Schrader, R; Juusola, J; Goker-Alpan, O; Milunsky, A; Schluter, A; Troncoso, M; Pujol, A; Tan, QKG; Schaaf, CP; Meng, LY (John Wiley and Sons Inc.P.O.Box 18667NewarkNJ 07191-8667, 2020)
    • Tru‐cut and Menghini needles: different yield in the histological diagnosis of liver disease 
      Vargas Tank, Ling; Martinez, Nora; Jirón,; Soto, C.; Armas-Merino, Rodolfo (1985)
      ABSTRACT— An evaluation of the information obtained by percutaneous liver biopsy performed with Travenol Tru‐cut® (“Tru‐cut”), Menghini's 1.9 and 1.6 needles, was done using cadavers. All needles used had a similar, low ...
    • Trypanosoma cruzi and toxoplasma gondii induce a differential MicroRNA profile in human placental explants 
      Medina, Lisvaneth; Castillo Rivas, Christian; Liempi, Ana; Guerrero Muñoz, Jesús; Rojas Pirela, Maura; Maya Arango, Juan Diego; Prieto, Humberto; Kemmerling Weis, Ulrike (Frontiers Media, 2020)
      Trypanosoma cruzi and Toxoplasma gondii are two parasites than can be transmitted from mother to child through the placenta. However, congenital transmission rates are low for T. cruzi and high for T. gondii. Infection ...
    • Trypanosoma cruzi burden, genotypes, and clinical evaluation of Chilean patients with chronic Chagas cardiopathy 
      Apt Baruch, Werner; Arribada, Arturo; Zulantay Alfaro, Inés; Saavedra, Miguel; Araya, Eduardo; Solari Illescas, Aldo; Ortiz, Sylvia; Arriagada, Katherine; Sánchez Rodríguez, Jorge E. (Springer Verlag, 2015)
      © 2015, The Author(s).There are currently no biomarkers to assess which patients with chronic indeterminate Chagas disease will develop heart disease and which will spend their entire life in this state. We hypothetize ...
    • Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with ... 
      Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina (Elsevier Ltd, 2014)
      Trypanosoma cruzi, the agent of Chagas' disease, the sixth neglected tropical disease worldwide, infects 10-12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes are complement-resistant ...
    • Trypanosoma cruzi calreticulin inhibits the complement lectinpathway activation by direct interaction with ... 
      Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira Vigouroux, Luis Arturo; Valck Calderón, Carolina Eliana (Elsevier, 2014)
      Trypanosoma cruzi, the agent of Chagas’ disease, the sixth neglected tropical disease worldwide, infects10–12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes arecomplement-resistant ...
    • Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface ... 
      Ramírez Toloza, Galia; Valck, Carolina; Molina, María C.; Ribeiro, Carolina Hager; López, Nandy; Sánchez, Gittith; Ferreira, Viviana P.; Billetta, Rosario; Aguilar, Lorena; Maldonado, Ismael; Cattan Ayala, Pedro; Schwaeble, Wilhelm; Ferreira Vigouroux, Luis Arturo (Elsevier, 2011)
      In Trypanosoma cruzi, calreticulin (TcCRT) translocates from the endoplasmic reticulum (ER) to the area of flagellum emergence. We propose herein that the parasite uses this molecule to capture complement C1, in an ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...
    • Trypanosoma cruzi calreticulin: In vitro modulation of key immunogenic markers of both canine tumors and ... 
      Cruz, P.; Sosoniuk Roche, E.; Maldonado, I.; Torres Mendoza, Cristián G.; Ferreira, A. (Elsevier, 2020)
      Recombinant calreticulin from Trypanosoma cruzi (rTcCalr), the parasite responsible for Chagas' disease, binds to Canine Transmissible Venereal Tumor (CTVT) cells from primary cultures and to a canine mammary carcinoma ...
    • Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to ... 
      Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Zago, M. Paola; Labriola, Carlos; Ferreira, Arturo; Basombrío, Miguel Ángel (2013-03)
      Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in ...
    • Trypanosoma cruzi diversity in infected dogs from areas of the north coast of Chile 
      Ortiz, S.; Ceballos, M. J.; González, C. R.; Reyes, C.; Gómez, V.; Martínez García, A.; Solari Illescas, Aldo (Elsevier B.V., 2016)
      © 2016 Elsevier B.V. As part of a multi-site research program on the eco-epidemiology and control of Chagas disease in northern Chile, we sought to identify the Trypanosoma cruzi discrete typing units (DTUs) infecting rural ...
    • Trypanosoma cruzi Genotypes of Insect Vectors and Patients with Chagas of Chile Studied by Means of Cytochrome ... 
      Arenas, Marco; Campos, Ricardo; Coronado, Ximena; Ortiz, Sylvia; Solari Illescas, Aldo (MARY ANN LIEBERT INC, 2012-03)
      Fifty-six Trypanosoma cruzi stocks from Chile and neighboring countries and different hosts, humans, and Triatoma infestans and Mepraia sp., vectors of domiciliary and natural environments were characterized by using three ...
    • Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a ... 
      Cura, Carolina I.; Mejía-Jaramillo, Ana M.; Duffy, Tomás; Burgos, Juan M.; Rodriguero, Marcela; Cardinal, Marta V.; Kjos, Sonia; Gurgel-Gonçalves, Rodrigo; Blanchet, Denis; De Pablos, Luis M.; Tomasini, Nicolás; da Silva, Alexandre; Russomando, Graciela; Cuba, Cesar A (2010)
      The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I (Tc I) infected biological samples, culture isolates and stocks from 11 endemic countries, from Argentina to the USA were characterised, ...
    • Trypanosoma cruzi increases the expression of cellular proliferation markers in ex vivo infected human ... 
      Liempi Manquel, Ana; Droguett Ossa, Daniel; Castillo, Christian; Gómez, Fresia; Negrete, Miguel; Carrillo, Ileana; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (Elsevier, 2015)
    • Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi 
      Duaso, J.; Rojo, G.; Jaña, F.; Galanti Garrone, Norbel; Cabrera, G.; Bosco, C.; López Muñoz, Rodrigo; Maya Arango, Juan; Ferreira, J.; Kemmerling Weis, Ulrike (2011)
      Chagas' disease, produced by the haemoflagellated protozoan Trypanosoma cruzi (T. cruzi), is one of the most frequent endemic diseases in Latin America. In spite that in the past few years T. cruzi congenital transmission ...