Now showing items 12390-12409 of 12946

    • Riquelme, Denise; Cerda Arancibia, Oscar Alejandro; Leiva Salcedo, Elías (Frontiers Media, 2021)
      TRPM4 is a non-selective cation channel activated by intracellular calcium and permeable to monovalent cations. This channel participates in the control of neuronal firing, neuronal plasticity, and neuronal death. TRPM4 ...
    • Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...
    • Sagredo, A.; Sagredo, Eduardo A.; Cappelli, Claudio; Baez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (John Wiley, 2018)
      Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...
    • Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)
      Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...
    • Gu, S; Chen, CA; Rosenfeld, JA; Cope, H; Launay, N; Flanigan, KM; Waldrop, MA; Schrader, R; Juusola, J; Goker-Alpan, O; Milunsky, A; Schluter, A; Troncoso, M; Pujol, A; Tan, QKG; Schaaf, CP; Meng, LY (John Wiley and Sons Inc.P.O.Box 18667NewarkNJ 07191-8667, 2020)
    • Vargas Tank, Ling; Martinez, Nora; Jirón,; Soto, C.; Armas-Merino, Rodolfo (1985)
      ABSTRACT— An evaluation of the information obtained by percutaneous liver biopsy performed with Travenol Tru‐cut® (“Tru‐cut”), Menghini's 1.9 and 1.6 needles, was done using cadavers. All needles used had a similar, low ...
    • Medina, Lisvaneth; Castillo Rivas, Christian; Liempi, Ana; Guerrero Muñoz, Jesús; Rojas Pirela, Maura; Maya Arango, Juan Diego; Prieto, Humberto; Kemmerling Weis, Ulrike (Frontiers Media, 2020)
      Trypanosoma cruzi and Toxoplasma gondii are two parasites than can be transmitted from mother to child through the placenta. However, congenital transmission rates are low for T. cruzi and high for T. gondii. Infection ...
    • Apt Baruch, Werner; Arribada, Arturo; Zulantay Alfaro, Inés; Saavedra, Miguel; Araya, Eduardo; Solari Illescas, Aldo; Ortiz, Sylvia; Arriagada, Katherine; Sánchez Rodríguez, Jorge E. (Springer Verlag, 2015)
      © 2015, The Author(s).There are currently no biomarkers to assess which patients with chronic indeterminate Chagas disease will develop heart disease and which will spend their entire life in this state. We hypothetize ...
    • Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina (Elsevier Ltd, 2014)
      Trypanosoma cruzi, the agent of Chagas' disease, the sixth neglected tropical disease worldwide, infects 10-12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes are complement-resistant ...
    • Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira Vigouroux, Luis Arturo; Valck Calderón, Carolina Eliana (Elsevier, 2014)
      Trypanosoma cruzi, the agent of Chagas’ disease, the sixth neglected tropical disease worldwide, infects10–12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes arecomplement-resistant ...
    • Ramírez Toloza, Galia; Valck, Carolina; Molina, María C.; Ribeiro, Carolina Hager; López, Nandy; Sánchez, Gittith; Ferreira, Viviana P.; Billetta, Rosario; Aguilar, Lorena; Maldonado, Ismael; Cattan Ayala, Pedro; Schwaeble, Wilhelm; Ferreira Vigouroux, Luis Arturo (Elsevier, 2011)
      In Trypanosoma cruzi, calreticulin (TcCRT) translocates from the endoplasmic reticulum (ER) to the area of flagellum emergence. We propose herein that the parasite uses this molecule to capture complement C1, in an ...
    • Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...
    • Cruz, P.; Sosoniuk Roche, E.; Maldonado, I.; Torres Mendoza, Cristián G.; Ferreira, A. (Elsevier, 2020)
      Recombinant calreticulin from Trypanosoma cruzi (rTcCalr), the parasite responsible for Chagas' disease, binds to Canine Transmissible Venereal Tumor (CTVT) cells from primary cultures and to a canine mammary carcinoma ...
    • Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Zago, M. Paola; Labriola, Carlos; Ferreira, Arturo; Basombrío, Miguel Ángel (2013-03)
      Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in ...
    • Ortiz, S.; Ceballos, M. J.; González, C. R.; Reyes, C.; Gómez, V.; Martínez García, A.; Solari Illescas, Aldo (Elsevier B.V., 2016)
      © 2016 Elsevier B.V. As part of a multi-site research program on the eco-epidemiology and control of Chagas disease in northern Chile, we sought to identify the Trypanosoma cruzi discrete typing units (DTUs) infecting rural ...
    • Arenas, Marco; Campos, Ricardo; Coronado, Ximena; Ortiz, Sylvia; Solari Illescas, Aldo (MARY ANN LIEBERT INC, 2012-03)
      Fifty-six Trypanosoma cruzi stocks from Chile and neighboring countries and different hosts, humans, and Triatoma infestans and Mepraia sp., vectors of domiciliary and natural environments were characterized by using three ...
    • Cura, Carolina I.; Mejía-Jaramillo, Ana M.; Duffy, Tomás; Burgos, Juan M.; Rodriguero, Marcela; Cardinal, Marta V.; Kjos, Sonia; Gurgel-Gonçalves, Rodrigo; Blanchet, Denis; De Pablos, Luis M.; Tomasini, Nicolás; da Silva, Alexandre; Russomando, Graciela; Cuba, Cesar A (2010)
      The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I (Tc I) infected biological samples, culture isolates and stocks from 11 endemic countries, from Argentina to the USA were characterised, ...
    • Liempi Manquel, Ana; Droguett Ossa, Daniel; Castillo, Christian; Gómez, Fresia; Negrete, Miguel; Carrillo, Ileana; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (Elsevier, 2015)
    • Duaso, J.; Rojo, G.; Jaña, F.; Galanti Garrone, Norbel; Cabrera, G.; Bosco, C.; López Muñoz, Rodrigo; Maya Arango, Juan; Ferreira, J.; Kemmerling Weis, Ulrike (2011)
      Chagas' disease, produced by the haemoflagellated protozoan Trypanosoma cruzi (T. cruzi), is one of the most frequent endemic diseases in Latin America. In spite that in the past few years T. cruzi congenital transmission ...
    • Droguett, Daniel; Carrillo, Ileana; Castillo, Christian; Gómez, Fresia; Negrete, Miguel; Liempi, Ana; Muñoz, Lorena; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Maya Arango, Juan; Droguett, Daniel (Academic Press Inc., 2017)
      © 2016 Elsevier Inc.Congenital transmission of Trypanosoma cruzi (T. cruzi) is partially responsible for the progressive globalization of Chagas disease. During congenital transmission the parasite must cross the placental ...