Browsing by Title Facultad de Medicina

Now showing items 12912-12931 of 12946

    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy 
      Hetz Flores, Claudio; Thielen, Peter; Matus, Soledad; Nassif, Melissa; Court, Felipe; Kiffin, Roberta; Martinez, Gabriela; Cuervo, Ana María; Brown, Robert H.; Glimcher, Laurie H. (2009)
      Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...
    • XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy 
      Matus, Soledad; Nassif, Melissa; Glimcher, Laurie H.; Hetz Flores, Claudio (Taylor and Francis Inc., 2009)
      Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...
    • Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ... 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Young Kim, Soo; Tong, Dan; Ferdous, Anwarul; Piristine, Hande; Dasgupta, Subhajit; Wang, Xuliang; French, Kristin M.; Villalobos, Elisa; Spurgin, Stephen B.; Waldman, Maayan; Jiang, Nan; May, Herman I.; Hill, Theodore M.; Luo, Yuxuan; Yoo, Heesoo; Zaha, Vlad G.; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2021)
      Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular ...
    • Xenodiagnosis 
      Schenone, Hugo (Fundacao Oswaldo Cruz, 1999)
    • Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated ... 
      Jaimovich Pérez, Enrique; Mattei, César; Liberona Leppe, José; Cárdenas, César; Estrada Hormazábal, Manuel; Barbier, Julien; Debitus, Cécile; Laurent, Dominique; Molgó, Jordi (ELSEVIER SCIENCE BV, 2005-04-11)
      Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ ...
    • An XRCC4 Splice Mutation Associated With Severe Short Stature, Gonadal Failure, and Early-Onset Metabolic Syndrome 
      Bruin, Christiaan de; Mericq, Verónica; Andrew, Shayne F.; Duyvenvoorde, Hermine A. van; Verkaik, Nicole S.; Losekoot, Monique; Porollo, Aleksey; Garcia, Hernán; Kuang, Yi; Hanson, Dan; Clayton, Peter; Gent, Dik C. van; Wit, Jan M.; Hwa, Vivian; Dauber, Andrew (The Endocrine Society, 2015)
      Context: Severe short stature can be caused by defects in numerous biological processes including defects in IGF-1 signaling, centromere function, cell cycle control, and DNA damage repair. Many syndromic causes of short ...
    • Y chromosome microdeletion prevalence in infertile Chilean men 
      Sánchez, Catherine; Vinay, José; Valdevenito Sepúlveda, Raúl; Palma Ceppi, Cristian (Elsevier, 2016)
      Objective: The aim of this study is to determine the prevalence of Y chromosome microdeletions in infertile Chilean men. Material and methods: A group of 102 infertile men with azoospermia or severe oligozoospermia were ...
    • Young woman, daughter of a father with alport’s syndrome, debuts with a impure nephrotic syndrome Mujer ... 
      González, Fernando; Méndez, Gonzalo; Navarrete, Daniela (Sociedad Medica de Santiago, 2017)
    • Your perspective and my benefit: multiple lesion models of self-other integration strategies during social ... 
      Melloni, Margherita; Billeke, Pablo; Báez, Sandra; Hesse, Eugenia; De La Fuente, Laura; Forno, Gonzalo; Birba, Agustina; García Cordero, Indira; Serrano, Cecilia; Plastino, Angelo; Slachevsky Chonchol, Andrea; Huepe, David; Sigman, Mariano; Manes, Facundo; García, Adolfo; Sedeno, Lucas; Ibañez, Agustín (Oxford University Press, 2016)
      Recursive social decision-making requires the use of flexible, context-sensitive long-term strategies for negotiation. To succeed in social bargaining, participants' own perspectives must be dynamically integrated with ...
    • ZEBI as a key promoter of tumoral progress in advanced stages of prostate cancer 
      Orellana Serradell, Octavio; Alvarado Herrera, Daniela José; Castellon Vera, Enrique; Contreras Muñoz, Héctor (Spandidos Publications Ltd., 2017)
    • Zebrafish as a model organism for nutrition and growth: Towards comparative studies of nutritional genomics ... 
      Ulloa, Pilar E.; Iturra, Patricia; Neira Roa, Roberto; Araneda, Cristian (2011)
      Zebrafish (Danio rerio) is a common research model in fish studies of toxicology, developmental biology, neurobiology and molecular genetics; it has been proposed as a possible model organism for nutrition and growth studies ...
    • Zebrafish BarH-like genes define discrete neural domains in the early embryo 
      Colombo, Alicia; Reig, Germán; Mione, Marina; Concha, Miguel L. (ELSEVIER, 2006-04)
      BarH (Barhl) genes encode for highly conserved homeodomain-containing transcription factors involved in critical functions during development, including cell fate specification, migration and survival. Here, we report the ...
    • Zebrafish neural crest: Lessons and tools to study in vivo cell migration 
      Alhashem Z., Portillo M.A.-G., Htun M.R., Gauert A., Montecinos L.B., Härtel S., Linker C. (Humana Press Inc., 2020)
    • Zika: probabilidad de establecimiento de su vector, Aedes aegypti, en Chile 
      Alaniz, Alberto J.; Bacigalupo, Antonella; Cattan Ayala, Pedro (Sociedad Chilena de Infectología, 2017)
      The Zika virus has raised world alarm in recent years, representing a major public health problem. In this study we evaluated the potential risk of exposure to Zika virus in Chile, associated with the probability of ...
    • Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: A randomized study using 2 supplements 
      Ruz, Manuel; Carrasco, Fernando; Arenas Rojas, Pamela; Codoceo, Juana; Inostroza, Jorge; Basfi-fer Obregón, Karen; Csendes Juhasz, Attila; Papapietro Vallejo, Karin; Pizarro Aguirre, Fernando; Olivares, Manuel; Sian, Lei; Westcott, Jamie L.; Miller, Leland V.; Hambidge, K. Michael; Krebs, Nancy F. (2011)
      Background: Micronutrient deficiencies are common in patients undergoing gastric bypass. The effect of this type of surgery on zinc absorption and zinc status is not well known. Objective: The objective was to evaluate the ...
    • Zinc absorption from a micronutrient-fortified dried cow's milk used in the Chilean National Complementary ... 
      Ruz, Manuel; Codoceo, Juana; Inostroza Escobar, Jorge; Rebolledo Acevedo, Annabella; Krebs, Nancy F.; Westcott, Jamie E.; Sian, Laei; Hambidge, K. Michael (PERGAMON-ELSEVIER SCIENCE, 2005-12)
      The objective was to compare the absorption of zinc from a micronutrient-fortified dried cow's milk, which is part of the Chilean National Complementary Food Program, with that from a standard nonfortified milk. Fortification ...
    • Zinc and iron interaction: Concepts and perspectives in the developing world 
      Solomons, Noel W.; Ruz, Manuel (1997)
      This paper reviews research published in recent years concerning the effects of zinc and iron interaction in both animal and humans. The information is discussed with particular emphasis on those situations relevant to the ...
    • Zinc as a potential coadjuvant in therapy for type 2 diabetes 
      Ruz Ortíz, Manuel; Carrasco Naranjo, Fernando; Rojas Mondaca, Pamela; Codoceo, Juana; Inostroza Escobar, Jorge; Basfi-fer Obregón, Karen; Valencia Canessa, Alejandra; Vásquez, Karla; Galgani Fuentes, José; Pérez, Alvaro; López, Gloria; Arredondo Olguín, Miguel; Pérez Bravo, Francisco (The United Nations University, 2013)
      Background: Type 2 diabetes is highly prevalent in populations having high rates of overweight and obesity. It is a chronic condition responsible for long-term severe dysfunction of several organs, including the ...
    • Zinc in plasma and breast milk in adolescents and adults in pregnancy and pospartum; a cohort study in Uruguay 
      Severi, Cecilia; Hambidge, Michael; Krebs, Nancy; Alonso, Rafael; Atalah Samur, Eduardo (2013)
      Objetivo: Evaluar la edad como factor de riego para el déficit nutricional de zinc en el embarazo y en el posparto y la correlación entre la concentración de zinc plasmático y de la leche materna. Diseño: Estudio de ...
    • Zinc in plasma and breast milk in adolescents and adults in pregnancy and pospartum; A cohort study in ... 
      Severi, Cecilia; Hambidge, Michael; Krebs, Nancy; Alonso, Rafael; Atalah, Eduardo (2013)
      Objective: To assess if age is a risk factor for low zinc nutritional status in pregnancy, postpartum and in breast milk concentration, and the association between mother zinc plasma level with zinc milk concentration. ...