Browsing by Title Facultad de Medicina

Now showing items 3588-3607 of 12970

    • Drug consumption in the masculine school population using the peer methodology and the standard self ... 
      Rodríguez T., Jorge; Valdés, C. Macarena; Fernández, Ana María; Dalbosco R., Daniela; Hoffman S., Marianela; Flores O., María Fernanda; Lee A., María Javiera; Ramírez F., Rafael; Ramírez P., Enrica; Pruzzo, Matías (2011)
      The objective of this study is to compare the declared licit and illicit drug consumption, between paired methodology (MP) and self assessed questionnaire (CAR). We suggest that understatement of illicit drug use will be ...
    • Drug interaction of voriconazole-cyclosporine in children undergoing hematopoietic stem cell transplantation ... 
      Valenzuela, Romina; Torres, Juan P.; Salas, Carolina; Sandoval Gajardo, Iván Elías; Palma, Julia; Catalán, Paula; Santolaya de Pablo, María Elena; Morales, Jorge (Sociedad Chilena de Infectologia, 2017)
      © 2017, Sociedad Chilena de Infectologia. All rights reserved.Background: Drug interactions (DI) in patients receiving hematopoietic stem cell transplantation (HSCT) are common and clinically significant, highlighting: ...
    • Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts 
      Mercado Guerra, María Gabriela; Hetz Flores, Claudio (Oxford University Press, 2017-06)
    • Drug-acetaldehyde interactions during ethanol metabolism in vitro 
      Núñez Vergara, Luis; Yudelevich, J.; Squella Serrano, Juan; Speisky Cosoy, Hernán (Oxford University Press, 1991)
      Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine ...
    • Drugs and porphyric crisis Fármacos y crisis porfírica. 
      Hernández,; Parraguez,; Wolff Fernández, Carlos; Armas-Merino, Rodolfo (1992)
      Life threatening crisis may accompany some varieties of porphyria like the acute intermittent form, coproporphyria, porphyria variegata and that associated to deficiency of porphobilinogen synthetase. Drugs are commonly ...
    • Dry needling technique decreases spasticity and improves general functioning in incomplete spinal cord ... 
      Cruz Montecinos, Carlos; Núñez Cortés, Rodrigo; Bruna Melo, Trinidad; Tapia, Claudio; Becerra, Pablo; Pavez, Nicolás; Pérez Alenda, Sofía (Taylor & Francis, 2020)
      Context: Spasticity in neurological disorders (i.e. stroke patients and cerebral palsy) is positively improved by dry needling. However, reports are scarce regarding the potential effects of dry needling in reducing ...
    • dSTORM microscopy evidences in HeLa cells clustered and scattered gamma H2AX nanofoci sensitive to ATM, ... 
      Liddle, Pablo; Jara Wilde, Jorge; Lafon Hughes, Laura; Castro, Iván; Hartel, Steffen; Folle, Gustavo (Springer, 2020)
      In response to DNA double-strand breaks (DSB), histone H2AX is phosphorylated around the lesion by a feed forward signal amplification loop, originating gamma H2AX foci detectable by immunofluorescence and confocal microscopy ...
    • DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity 
      Muñoz, Patricia; Cárdenas, Sergio; Huenchuguala, Sandro; Briceño, Andrea; Couve, Eduardo; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Oxford University Press, 2015)
      It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
    • DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells 
      Meléndez, Catalina; Muñoz, Patricia; Segura Aguilar, Juan (Springer, 2019)
      Aminochrome has been reported to induce lysosomal dysfunction by inhibiting the vacuolar H-type ATPase localized inlysosome membrane. DT-diaphorase has been proposed to prevent aminochrome neurotoxicity but it is unknown ...
    • DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers 
      Muñoz, Patricia S.; Segura Aguilar, Juan (Springer, 2017)
      Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
    • DT-diaphorase protects astrocytes from aminochrome-induced toxicity 
      Huenchuguala, Sandro; Muñoz, Patricia; Graumann, Rebecca; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Elsevier, 2016)
      Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
    • Dual and opposite roles of reactive oxygen species (ROS) in chagas disease: beneficial on the pathogen and ... 
      Maldonado Maldonado, Edio; Rojas, Diego A.; Morales, Sebastián; Miralles, Vicente; Solari Illescas, Aldo (Hindawi, 2020)
      Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary ...
    • Dual innervation of the brachialis muscle in the Chilean population Doble inervación del músculo braquial ... 
      Molina, Claudio; Uribe, Cristián; Heras, Álvaro; Astorga, Cristián; Lemus, Jorge; Rodríguez, Alberto (2011)
      The dual innervation of the brachialis muscle by the musculocutaneos nerve and branches from the radial nerve has been described by some anatomical texts and several scientific papers; however, there is no consensus about ...
    • Dual inotropic effect of harmaline on the rat heart atrial muscle 
      Carpenter, Robert; Diaz, Gabriela (1977)
      The effect of harmaline (HME) was analyzed in rat strips superfused in vitro. A dual inotropic action was found: the positive component was due to a transient catechol-mediated enhancement of the velocity of development ...
    • Dual IRE1 RNase functions dictate glioblastoma development 
      Lhomond, Stephanie; Avril, Tony; Dejeans, Nicolas; Hetz Flores, Claudio (Wiley, 2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
    • Dual modifications of alpha-galactosylceramide synergize to promote activation of human invariant natural ... 
      Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño Marquez, Leandro J.; Guberman-Pfeffer, Matthew J.; Arora, Pooja; Yongqing, Tan; Koay, Hui-Fern); Godfrey, Dale I.; Keshipeddy, Santosh; Richardson, Stewart K.; Sundararaj, Srinivasan; Lo, Jae Ho; Wen, Xiangshu; Gascón, José A.; Yuan, Weiming; Rossjohn, Jamie; Le Nours, Jéroˆme; Porcelli, Steven A.; Howell, Amy R. (Cell press, 2018-05-17)
      Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous studies using mouse ...
    • Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer ... 
      Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño, Leandro J.; Guberman-Pfeffer, Matthew J.; Arora, Pooja; Yongqing, Tang; Koay, Hui Fern; Godfrey, Dale I.; Keshipeddy, Santosh; Richardson, Stewart K.; Sundararaj, Srinivasan; Lo, Jae Ho; Wen, Xiangshu; (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous ...
    • Dual-task gait as a predictive tool for cognitive impairment in older adults: a systematic review 
      Ramírez, Felipe; Gutiérrez, Myriam (Frontiers Media, 2021)
      The use of the dual-task model as a cognitive-motor interface has been extensively investigated in cross-sectional studies as a training task in cognitive impairment. However, few existing longitudinal studies prove the ...
    • Duality of tocopherol isoforms and novel associations with vitamins involved in one-carbon metabolism: ... 
      Sotomayor, Camilo G.; Minovic, Isidor; Eggersdorfer, Manfred L.; Riphagen, Ineke J.; de Borst, Martin H.; Dekker, Louise H.; Nolte, Ilja M.; Frank, Jan; Van Zon, Sander K. R.; Reijneveld, Sijmen A.; Van Der Molen, Jan C.; Vos, Michel J.; Kootstra-Ros, Jenny E.; Rodrigo Salinas, Ramón; Kema, Ido P.; Navis, Gerjan J.; Bakker, Stephan J.L. (MDPI, 2020)
      Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear ...
    • Ductal epithelial lesions and pancreatic adenocarcinoma 
      Bentjerodt, R.; Smok Sahid, Gladys (1990)
      Epithelial alterations in pancreatic ducts may have a premalignant nature. We compared the incidence of different lesions in 49 pancreatic cancer specimens compared to 100 controls. Simple hyperplasia, mucosecretory ...