Browsing by Author "Quest, Andrew F. G."

Now showing items 41-49 of 49

    • Severe alterations in expression and localisation of α6β4 integrin in salivary gland acini from patients ... 
      Velozo, J.; Aguilera, S.; Alliende, C.; Ewert, P.; Molina, C.; Pérez, P.; Leyton, L.; Quest, Andrew F. G.; Brito, M.; González, S.; Leyton, C.; Hermoso Ramello, Marcela; Romo, R.; González, M. J. (2009)
      Objectives: In salivary glands from patients with Sjögren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina ...
    • Signaling triggered by Thy-1 interaction with β3 integrin on astrocytes is an essential step towards ... 
      Avalos, Ana Maria; Labra, Cecilia V.; Quest, Andrew F. G.; Leyton Campos, Lisette (2002)
      Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with β3 integrin ...
    • Sjögren's syndrome and the epithelial target: A comprehensive review 
      Barrera, M. J.; Bahamondes, V.; Sepúlveda, D.; Quest, Andrew F. G.; Castro, I.; Cortés, J.; Aguilera, S.; Urzúa, U.; Molina, C.; Pérez, P.; Ewert, P.; Alliende, C.; Hermoso, M. A.; González, S.; Leyton, C.; González, M. J. (2013)
      The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the ...
    • Supramolecular complex formation in cell signaling and disease: An update on a recurrent theme in cell life ... 
      Leyton Campos, Lisette; Quest, Andrew F. G. (Society of Biology of Chile, 2004)
      In summary, this limited discussion of recent developments concerning a few signaling pathways and associated cellular systems hopefully underscores the importance of multiprotein complex formation in cellular signaling, ...
    • Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent ... 
      Fernández, Jaime G.; Rodríguez, Diego A.; Valenzuela, Manuel; Calderon, Claudia; Urzúa, Ulises; Munroe, David; Rosas, Carlos; Lemus, David; Díaz, Natalia; Wright, Mathew C.; Leyton Campos, Lisette; Tapia, Julio C.; Quest, Andrew F. G. (BioMed Central Ltd., 2014)
      © 2014 Fernández et al.; licensee BioMed Central Ltd.Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an ...
    • The Caveolin-1 connection to cell death and survival 
      Quest, Andrew F. G.; Lobos González, Lorena; Nuñez, S.; Sanhueza, C.; Fernández, J. G.; Aguirre, A.; Rodríguez, D.; Leyton, L.; Torres, V. (2013)
      Caveolins are a family of membrane proteins required for the formation of small plasma membrane invaginations called caveolae that are implicated in cellular trafficking processes. In addition to this structural role, these ...
    • Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 
      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Alvarez, Alvaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both ...
    • TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway 
      Armisen Yáñez, Ricardo; Marcelain Cubillos, Katherine; Simon, Felipe; Tapia, Julio C.; Toro, Jessica; Quest, Andrew F. G.; Stutzin Schottlander, Andrés (2011)
      Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin ...
    • Tumor Suppression and Promotion by Autophagy 
      Ávalos, Yenniffer; Canales, Jimena; Bravo Sagua, Roberto; Criollo Céspedes, Alfredo; Lavandero González, Sergio; Quest, Andrew F. G. (Hindawi, 2014)
      Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems ...