Browsing by Author "Kalergis, Alexis M."

Now showing items 1-11 of 11

    • Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity 
      Herrada, Andrés A.; Contreras, Francisco J.; Marini, Natacha P.; Amador, Cristian A.; González, Pablo A.; Cortés, Claudia M.; Riedel, Claudia A.; Carvajal, Cristián A.; Figueroa, Fernando; Michea Acevedo, Luis; Fardella, Carlos E.; Kalergis, Alexis M. (American Association of Immunologists, 2010)
      Excessive production of aldosterone leads to the development of hypertension and cardiovascular disease by generating an inflammatory state that can be promoted by T cell immunity. Because nature and intensity of T cell ...
    • Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at ... 
      Pacheco, Rodrigo; Quezada, Sergio A.; Kalergis, Alexis M.; Becker, María Inés; Ferreira, Jorge; Ioannes, Alfredo E. de (Sociedad de Biología de Chile, 2021)
      Background: Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ efector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate innate ...
    • B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, ... 
      Catalán Martina, Diego; Aravena, Octavio; Sabugo, Francisca; Wurmann, Pamela; Soto, Lilian; Kalergis, Alexis M.; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos (2010)
      Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
    • The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells ... 
      Bueno, Susan; González, Pablo A.; Carreño Márquez, Leandro; Tobar, Jaime A.; Mora, Guido C.; Pereda, Cristián; Salazar Onfray, Flavio; Kalergis, Alexis M. (BLACKWELL, 2008-08)
      Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived ...
    • Characterization of the anti-inflammatory capacity of IL-10-producing neutrophils in response to Streptococcus ... 
      González, Liliana A.; Melo González, Felipe; Sebastián, Valentina P.; Vallejos, Omar P.; Noguera, Loreani P.; Suazo, Isidora D.; Schultz Lombardic, Barbara Melinka; Manosalva, Andrés H.; Peñaloza, Hernán F.; Soto, Jorge A.; Parker, Dane; Riedel, Claudia A.; González, Pablo A.; Kalergis, Alexis M.; Bueno, Susan M. (Frontiers Media, 2021)
      Neutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung ...
    • Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by ... 
      Arriagada, Alejandro A.; Albornoz, Eduardo; Opazo, María Cecilia; Becerra, Álvaro; Vidal, Gonzalo; Fardella, Carlos; Michea Acevedo, Luis; Carrasco, Nancy; Simón, Felipe; Elorza, Álvaro A.; Bueno, Susan M.; Kalergis, Alexis M.; Riedel, Claudia A. (Endocrine Society, 2015)
      Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
    • Iodine Intake Based on a Survey from a Cohort of Women at Their Third Trimester of Pregnancy from the Bosque ... 
      Opazo, María Cecilia; Fuentes Pena, Camilo; Méndez, Luis; Rojas, Diana; Aguayo, Daniel; Oyanedel, Juan Carlos; Moreno Reyes, Rodrigo; Wohllk González, Nelson Jorge; Kalergis, Alexis M.; Riedel, Claudia A. (Springer, 2023)
      Adequate iodine nutrition is fundamental for all humans and is critical during pregnancy and lactation due to iodine forms part of the structure of thyroid hormones (THs) and it is required for THs function. Iodine is a ...
    • Maternal Hypothyroxinemia impairs Spatial Learning and Synaptic nature and function in the Offspring 
      Opazo, M. C.; Gianini, A.; Pancetti, F.; Azkcona, G.; Alarcón, L.; Lizana, R.; Noches, V.; Gonzalez, P. A.; Porto, M.; Mora Gutiérrez, Sergio; Rosenthal, D.; Eugenin, E.; Naranjo, D.; Kalergis, Alexis M.; Riedel, Claudia A. (Endocrine Society, 2008-10)
      Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand the mechanism responsible for these neurological alterations, we induced maternal hypothyroxinemia ...
    • Modulation of endosome function, vesicle trafficking and autophagy by human herpesviruses 
      Tognarelli, Eduardo; Reyes, Antonia; Corrales, Nicolás; Carreño Marquez, Leandro Javier; Bueno, Susan; Kalergis, Alexis M.; González, Pablo A. (MDPI, 2021)
      Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin ...
    • Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases 
      Mackern-Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M. (Elsevier, 2015)
      Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory ...
    • Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic ... 
      Salazar, Lorena; Aravena, Octavio; Contreras Levicoy, Juan; Pesce Reyes, Bárbara; Catalán Martina, Diego; Zúñiga, Roberto; Iruretagoyena, Mirentxu; Kalergis, Alexis M.; Aguillón Gutiérrez, Juan Carlos (2007)
      Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...