Browsing by Author "Saá, Paula"

Now showing items 1-2 of 2

    • Cell-free propagation of prion strains 
      Castilla, Joaquín; Morales, Rodrigo; Saá, Paula; Barría, Marcelo; Gambetti, Pierluigi; Soto, Claudio (NATURE PUBLISHING GROUP, 2008-10-08)
      Prions are the infectious agents responsible for prion diseases, which appear to be composed exclusively by the misfolded prion protein (PrPSc). Disease is transmitted by the autocatalytic propagation of PrPSc misfolding ...
    • Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions 
      Castilla, Joaquín; González Romero, Dennisse; Saá, Paula; Morales, Rodrigo; Castro, Jorge de; Soto, Claudio (CELL PRESS, 2008-09-05)
      Prions are unconventional infectious agents composed exclusively of misfolded prion protein (PrPSc), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrPC). A key ...