Browsing by Author "Speisky Cosoy, Hernán"
Now showing items 1-8 of 8
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Speisky Cosoy, Hernán; Cassels Niven, Bruce; Lissi Gervaso, Eduardo A.; Videla Cabrera, Luis (1991)Boldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation ...
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Carrasco Pozo, Catalina; Speisky Cosoy, Hernán; Brunser, Oscar; Pastene, Edgar; Gotteland, Martin (2011)The stability of an apple peel polyphenol extract (APPE) with powerful antioxidant activity was evaluated under acidic conditions in vitro, and its protective effect against gastrointestinal damage was investigated in rats ...
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Pastene, Edgar; Troncoso, Miriam; Figueroa, Guillermo; Alarcón, Julio; Speisky Cosoy, Hernán (2009)Apple peel extracts and their fractions pooled according to their molecular size were prepared and evaluated for their inhibitory activity against Helicobacter pylori and Jack bean ureases. Urease Inhibitory effect of apple ...
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Núñez Vergara, Luis; Yudelevich, J.; Squella Serrano, Juan; Speisky Cosoy, Hernán (Oxford University Press, 1991)Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine ...
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Pastene, Edgar; Speisky Cosoy, Hernán; García, Apolinaria; Moreno, Jessica; Troncoso, Miriam; Figueroa, Guillermo (2010)The inhibitory effects of a standarized apple peel polyphenol-rich extract (APPE) against Helicobacter pylori infection and vacuolating bacterial toxin (VacA) induced vacuolation were investigated. Apple peel polyphenols ...
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Pastene, Edgar; Speisky Cosoy, Hernán; Troncoso, Miriam; Alarcón, Julio; Figueroa, Guillermo (2009)In the present work, the in vitro effect of a standardized extract of apple peel APPE (60% of total polyphenols; 58% of flavonoids; 30% of flavan-3-ols and procyanidins) was evaluated with regard to the viability of ...
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Sandoval Acuña, Cristian; López Alarcón, Camilo; Aliaga, Margarita E.; Speisky Cosoy, Hernán (2012)Mitochondrial dysfunction plays a major role in the development of oxidative stress and cytotoxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs). A major objective of the present study was to investigate ...
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Speisky Cosoy, Hernán; Squella Serrano, Juan; Núñez Vergara, Luis (1995)This article critically reviews the recent specialized literature concerning the influence of the stereochemical nature of quiral drugs on the pharmacokinetic processes and its pharmacological implications. Evidence is ...