Browsing by Subject "IGF-1"

Now showing items 1-5 of 5

    • Activating GNAS1 gene mutations in patients with premature thelarche 
      Román, Rossana; Johnson, María Cecilia; Codner Dujovne, Ethel; Boric Scarpa, María Angélica; Ávila, Alejandra; Cassorla Goluboff, Fernando (2004)
      Objective To identify GNAS1 gene mutations in girls with exaggerated and/or chronic fluctuating thelarche for at least 1-year duration with no other signs of precocious puberty, skeletal dysplasia, or typical skin lesions ...
    • Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and ... 
      Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza Fuentes, Pía; Muñoz, Claudia; Díaz Araya, Guillermo (2012)
      Cardiac fibroblast (CF) death by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. Although IGF-1 has well-known cytoprotective effects, no study has been done on CF subjected to simulated ...
    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 
      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Growth hormone signaling in fibroblasts from newborn boys and prepubertal boys 
      Ocaranza Osses, Paula; Morales, Fernanda; Matamala, Álvaro; Gaete, Ximena; Román, Rossana; Lammoglia, Juan Javier; Cassorla Goluboff, Fernando (Elsevier, 2016-04)
      Background/aim: Responsiveness to GH in target cells is mediated by its receptor, which activates the Janus kinase-2 (JAK2) and STAT5 (signal transducers and activators of transcription 5) leading to the expression of IGF-1 ...
    • Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children 
      Ugarte, Francisca; Irarrázabal, Carlos; Oh, Jun; Dettmar, Anne; Ceballos, María L.; Rojo, Angélica; Ibacache, M. José; Suazo, Cristián; Lozano, Mauricio; Delgado B., Iris; Cavada Chacón, Gabriel; Azócar Pruyas, Marta; Delucchi Bicocchi, María Angela; Cano Schuffeneger, Francisco (Springer, 2016)
      Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation of Janus ...