Browsing by Subject "IL-33"

Now showing items 1-6 of 6

    • Alarmin’ immunologists: iL-33 as a putative target for modulating T cell-dependent responses 
      Gajardo Carrasco, Tania; Morales, Rodrigo A.; Pérez Bravo, Francisco; Terraza, Claudia; Yáñez, Luz; Campos Mora, Mauricio; Pino Lagos, Karina (Frontiers Research Foundation, 2015)
      IL-33 is a known member of the IL-1 cytokine superfamily classically named “atypical” due to its diverse functions. The receptor for this cytokine is the ST2 chain (or IL-1RL1), part of the IL-1R family, and the accessory ...
    • Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease 
      Beltrán, Caroll J.; Núñez, Lucía E.; Díaz Jiménez, David; Farfán, Nancy; Candia, Enzo; Heine, Claudio; López, Francisco; González Burgos, María Julieta; Quera Pino, Rodrigo; Hermoso Ramello, Marcela (2010)
      Background: ST2 has been proposed to be a regulator of inflammation and Th1/Th2 balance. ST2L is the IL-33 membrane receptor and belongs to the IL-1R family. The soluble variant, ST2s, is identical to the extracellular ...
    • High level of interleukin-33 in cancer cells and cancer-associated fibroblasts correlates with good prognosis ... 
      Yangngam, Supaporn; Thongchot, Suyanee; Pongpaibul, Ananya; Vaeteewoottacharn, Kulthida; Pinlaor, Somchai; Thuwajit, Peti; Okada, Seiji; Hermoso Ramello, Marcela; Thuwajit, Chanitra (Ivyspring International Publisher, 2020)
      Interleukin 33 (IL-33) promotes cholangiocarcinoma (CCA) genesis in a mouse model, however, its function in human CCA has not been clearly understood. This study was aimed to investigate IL-33 level in CCA tissues and its ...
    • IL-33 Alarmin and its active proinflammatory fragments are released in small intestine in celiac disease 
      Pérez, Federico; Ruera, Carolina N.; Miculan, Emanuel; Carasi, Paula; Dubois Camacho, Karen; Garbi, Laura; Guzmán, Luciana; Hermoso, Marcela; Chirdo, Fernando G. (Frontiers Media, 2020)
      Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acting as a gene regulator, it can be also ...
    • IL-33 enhances retinoic acid signaling on CD4+T cells 
      Gajardo, Tania; Pérez, Francisco; Terraza, Claudia; Campos Mora, Mauricio; Noelle, Randolph J.; Pino Lagos, Karina (Elsevier, 2016)
      Several molecules have been described as CD4+ T cells differentiation modulators and among them retinoic acid (RA) and more recently, IL-33, have been studied. Due to the similarities in T helper cell skewing properties ...
    • The IL-33/ST2 axis: Role in health and disease 
      Fuente, Marjorie de la; MacDonald, Thomas T.; Hermoso Ramello, Marcela (Elsevier, 2015)
      IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a ...