Browsing by Subject "Immunology"

Now showing items 1-20 of 83

    • A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the ... 
      Burmester, Gerd R.; McInnes, Iain B.; Kremer, Joel; Miranda, Pedro; Korkosz, Mariusz; Vencovsky, Jiri; Rubbert-Roth, Andrea; Mysler, Eduardo; Sleeman, Matthew A.; Godwood, Alex; Sinibaldi, Dominic; Guo, Xiang; White, Wendy I.; Wang, Bing; Wu, Chi Yuan; Ryan, Patricia C. (BMJ Publishing Group, 2017)
      Objectives: Despite the therapeutic value of current rheumatoid arthritis (RA) treatments, agents with alternative modes of action are required. Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage ...
    • A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class ... 
      Kurte, Mónica; López, Mercedes; Aguirre, Adam; Escobar, Alejandro; Aguillón Gutiérrez, Juan Carlos; Charo, Jehad; Larsen, Christian G.; Kiessling, Rolf; Salazar Onfray, Flavio (American Association of Immunologists, 2004)
      Tumor cells treated with IL-10 were shown to have decreased, but peptide-inducible expression of MHC class I, decreased sensitivity to MHC class I-restricted CTL, and increased NK sensitivity. These findings could be ...
    • Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the ... 
      Villablanca, Eduardo J.; Pistocchi, Anna; Court, Felipe A.; Cotelli, Franco; Bordignon, Claudio; Allende Connelly, Miguel; Traversari, Catia; Russo, Vincenzo (American Association of Immunologists, 2007)
      PGE2 is involved in a wide variety of physiological and pathological processes; however, deciphering its role in early mammalian development has been difficult due to the maternal contribution of PGE 2. To overcome this ...
    • Acute gouty arthritis without urate crystals identified on initial examination of synovial fluid 
      Schumacher, H. Ralph; Jimenez, Sergio A.; Gibson, Terry; Pascual, Eliseo; Traycof, Roger; Dorwart, Bonnie B.; Reginato, Antonio J. (1975)
      Nine patients who ultimately proved to have acute gouty arthritis did not have urate crystals demonstrable by compensated polarized light in the first joint fluid aspirated despite leukocyte counts as high as 100,000/mm3. ...
    • Allergenicity of lentils in the South of Chile . Reporting a case and review Alergia a la proteína de ... 
      Saint-Pierre, G.; Pizarro, C.; Rojas, M.; Valencia, M. (Asociation Argentina de Dermatologia, 2018)
      © 2018 Asociation Argentina de Dermatologia. All rights reserved. The food allergy, involves entities as diverse as cow's milk protein to peanut allergies as to legumes. The global prevalence of this entity has been ...
    • Analysis of human rotavirus mixed electropherotypes 
      Spencer, Nicolás; Avendano, Octavio; GARCIA, (1983)
      Mixed human rotavirus electropherotypes were detected in stool samples from patients with acute gastroenteritis in Santiago, Chile. These electropherotypes accounted for 10% of 149 samples studied. The finding of extra RNA ...
    • Ancient HTLV type 1 provirus DNA of andean mummy 
      Sonoda, S.; Li, H. C.; Cartier Rovirosa, Luis; Núñez, L.; Tajima, K. (2000)
      The worldwide geographic and ethnic clustering of patients with diseases related to human T cell lymphotropic virus type 1 (HTLV-1) may be explained by the natural history of HTLV-1 infection. The genetic characteristics ...
    • Antimalarial treatment may have a time-dependent effect on lupus survival: Data from a multinational Latin ... 
      Shinjo, Samuel K.; Bonfá, Eloísa; Wojdyla, Daniel; Borba, Eduardo F.; Ramirez, Luis A.; Scherbarth, Hugo R.; Tavares Brenol, João C.; Chacón Díaz, Rosa; Neira, Oscar J.; Berbotto, Guillermo A.; De La Torre, Ignacio Garcia; Acevedo Vásquez, Eduardo; Massardo, Loret (John Wiley and Sons Inc., 2010)
      Objective. To evaluate the beneficial effect of antimalarial treatment on lupus survival in a large, multiethnic, international longitudinal inception cohort. Methods. Socioeconomic and demographic characteristics, clinical ...
    • Antinociceptive interaction of (±)-CPP and propentofylline in monoarthritic rats 
      Morales, Francisco; Constandil, Luis; Pelissier Serrano, Teresa; Hernández, Alejandro; Laurido, Claudio (2012)
      Introduction: Multiple studies have shown that glial cells of the spinal cord, such as astrocytes and microglia, have close contact with neurons, suggesting the term tripartite synapse. In these synapses, astrocytes ...
    • B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, ... 
      Catalán Martina, Diego; Aravena, Octavio; Sabugo, Francisca; Wurmann, Pamela; Soto, Lilian; Kalergis, Alexis M.; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos (2010)
      Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
    • Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's ... 
      Molina, C.; Alliende, C.; Aguilera, S.; Kwon, Y. J.; Leyton, L.; Martínez, B.; Leyton, C.; Pérez, P.; González Burgos, María Julieta (2006)
      Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren's syndrome, and to relate ...
    • Biochemical, immunological, and biological characterization of trypanosoma cruzi populations of the andean ... 
      ; Gonzalez, J.; Muñoz, S.; Ortiz, S.; Anacona, D.; Salgado, S.; Galleguillos, M.; Neira, I.; Sagua, H.; Solari Illescas, Aldo (1995)
      Twenty-one Trypanosoma cruzi stocks isolated from Triatoma infestans and humans of the Chilean Andean highlands were studied at the genotypic level by schizodeme and molecular karyotype analyses, which allowed a clear ...
    • Biological characterization of Trypanosoma cruzi stocks from Chilean insect vectors 
      Solari Illescas, Aldo; Wallace, A.; Ortiz, S.; Venegas, J.; Sanchez, G. (Academic Press Inc., 1998)
      Fifty-seven Trypanosoma cruzi stocks isolated from Triatoma infestans and Triatoma spinolai of the five different geographic endemic areas of Chile were studied by schizodeme and molecular karyotype analysis. Four different ...
    • Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic ... 
      Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Hager Ribeiro, Carolina; Molina, María C.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
    • Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Ma (2011)
      Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Characteristics and analysis of electropherotypes of human rotavirus isolated in Chile 
      Spencer, Eugenio; Avendaño, Fidel; Araya, Magdalena (1983)
      Electropherotypes of human rotavirus from stool samples of hospitalized and ambulatory infants with acute diarrhea were analysed. Thirty-two different electropherotypes were observed in 142 cases in which the viral genome ...
    • Clinical study of hereditary disorders of connective tissues in a chilean population: Joint hypermobility ... 
      Bravo, Jaime F.; Wolff Fernández, Carlos (2006)
      Objective. To demonstrate the high frequency and lack of diagnosis of joint hypermobility syndrome (JHS) and the seriousness of vascular Ehlers-Banlos syndrome (VEDS). Methods. Two hundred forty-nine Chilean patients with ...
    • Correction to Blondel et al., The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 ... 
      Blondel, Carlos J.; Jiménez, Juan C.; Leiva, Lorenzo E.; álvarez, Sergio A.; Pinto, Bernardo I.; Contreras, Francisca; Pezoa, David; Santiviago Cid, Carlos; Contreras, Inés (American Society for Microbiology, 2015)
    • De novo generation of infectious prions in vitro produces a new disease phenotype 
      Barría, Marcelo; Mukherjee, Abhisek; González Romero, Dennisse; Morales, Rodrigo; Soto, Claudio (2009)
      Prions are the proteinaceous infectious agents responsible for Transmissible Spongiform Encephalopathies. Compelling evidence supports the hypothesis that prions are composed exclusively of a misfolded version of the prion ...
    • Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to ... 
      Ewert, Patricia; Aguilera, Sergio; Alliende, Cecilia; Kwon, Yoon Jeoung; Albornoz, Amelina; Molina, Claudio; Urzúa, Ulises; Quest, Andrew F. G.; Olea, Nancy; Pérez, Paola; Castro, Isabel; Barrera, María José; Romo, Rafael; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Mar (2010)
      Objective. Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's ...