Browsing by Subject "Ubiquitin-proteasome system"

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    • Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor 
      Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)
      Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...