Browsing by Author "Segura Aguilar, Juan Ernesto"

Now showing items 1-3 of 3

    • Dopamine and L-Dopa as selective endogenous neurotoxins 
      Segura Aguilar, Juan Ernesto; Ahumada Castro, Ulises; Paris, Irmgard (2023)
      Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine transporter. The possible molecular mechanisms involved in dopamine and ...
    • Mechanisms of Dopamine Oxidation and Parkinson’s Disease 
      Segura Aguilar, Juan Ernesto; Paris, Irmgard (Springer, 2023)
      Dopamine’s ability to oxidize to aminochrome explains why this molecule may be a neurotoxic compound that induces toxicity in both cell lines and animal models. Spontaneous dopamine oxidation is prevented by vesicular ...
    • RCSN Cell System for Identifying Dopaminergic Neurotoxicity 
      Caviedes Fernández, Pablo Andrés; Caviedes, Raúl; Segura Aguilar, Juan Ernesto (Springer, 2022)
      Dopaminergic toxicity represents a potential mechanism underlying Parkinson’s disease (PD) neuropathology. Nevertheless, the study of such a mechanism is hampered by the lack of permanent and stable in vitro models that ...