Show simple item record

Authordc.contributor.authorParraguez Gamboa, Víctor es_CL
Authordc.contributor.authorAtlagich, Miljenko es_CL
Authordc.contributor.authorAraneda, Oscar es_CL
Authordc.contributor.authorGarcía, Carlos es_CL
Authordc.contributor.authorMuñoz, Andrés es_CL
Authordc.contributor.authorReyes Solovera, Mónica de los es_CL
Authordc.contributor.authorUrquieta, Bessie 
Admission datedc.date.accessioned2011-11-29T18:40:45Z
Available datedc.date.available2011-11-29T18:40:45Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationREPRODUCTION FERTILITY AND DEVELOPMENT Volume: 23 Issue: 2 Pages: 285-296 Published: 2011es_CL
Identifierdc.identifier.issn1031-3613
Identifierdc.identifier.otherDOI: 10.1071/RD10016
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/122419
General notedc.descriptionArtículo de publicación ISIes_CL
Abstractdc.description.abstractThe present study evaluated the hypothesis that the effects of hypoxia on sheep pregnancies at high altitude (HA) are mediated by oxidative stress and that antioxidant vitamins may prevent these effects. Both HA native and newcomer ewes were maintained at an altitude of 3589m during mating and pregnancy. Control low altitude (LA) native ewes were maintained at sea level. Half of each group received daily oral supplements of vitamins C (500 mg) and E (350 IU) during mating and gestation. Near term, maternal plasma vitamin levels and oxidative stress biomarkers were measured. At delivery, lambs were weighed and measured, and placentas were recovered for macroscopic and microscopic evaluation. Vitamin concentrations in supplemented ewes were two-or threefold greater than in non-supplemented ewes. Plasma carbonyls and malondialdehyde in non-supplemented ewes were consistent with a state of oxidative stress, which was prevented by vitamin supplementation. Vitamin supplementation increased lamb birthweight and cotyledon number in both HA native and newcomer ewes, although placental weight and cotyledon surface were diminished. Placentas from vitamin-supplemented HA ewes were similar to those from ewes at sea level, making these placental traits (weight, number and diameter of cotyledons) similar to those from ewes at sea level. Vitamin supplementation had no effect on LA pregnancies. In conclusion, supplementation with vitamins C and E during pregnancy at HA prevents oxidative stress, improving pregnancy outcomes.es_CL
Patrocinadordc.description.sponsorshipCONICYT, Chile FONDECYT 1020706 1070405es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherCSIRO PUBLISHINGes_CL
Keywordsdc.subjecthypoxiaes_CL
Títulodc.titleEffects of antioxidant vitamins on newborn and placental traits in gestations at high altitude: comparative study in high and low altitude native sheepes_CL
Document typedc.typeArtículo de revistaes_CL


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record