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Authordc.contributor.authorBrahm Barril, Javier 
Authordc.contributor.authorBrahm, Magdalena es_CL
Authordc.contributor.authorSegovia, Roberto es_CL
Authordc.contributor.authorBuckel González, Erwin es_CL
Authordc.contributor.authorLatorre, Ricardo es_CL
Authordc.contributor.authorPoniachik Teller, Jaime es_CL
Authordc.contributor.authorZapata, Rodrigo es_CL
Authordc.contributor.authorContreras, Luis es_CL
Admission datedc.date.accessioned2011-06-03T14:55:35Z
Available datedc.date.available2011-06-03T14:55:35Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationANNALS OF HEPATOLOGY Volume: 10 Issue: 1 Pages: 93-98 Published: JAN-MAR 2011es_CL
Identifierdc.identifier.issn1665-2681
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/124183
General notedc.descriptionArtículo de publicación ISIes_CL
Abstractdc.description.abstractFlutamide is a non-steroidal anti-androgenic drug, commonly used in the treatment of advanced prostate cancer, acne and hirsutism. This drug may induce various degrees of liver injury, including acute liver failure (ALF), with further need for liver transplantation. Here, we present a report of 10 consecutive patients seen in a period of 14 years, with acute liver toxicity induced by flutamide (in most cases severe hepatotoxicity): 3 men and 7 women, with a mean age of 75 and 29 years old, respectively. All men received flutamide as treatment of advanced prostate carcinoma and they developed hepatotoxicity without ALF, and three months after withdrawal of the drug, they recovered completely. In contrast, in 7 young female with liver toxicity caused by flutamide as treatment of various hyperandrogenic conditions (acne and hirsutism), ALF was observed in 5 patients, all of them requiring urgent liver transplantation, with excellent outcome and survival in 4 of them. Based on the above, we believe that flutamide treatment should be preferentially avoided in young female patients with benign pathologies, or if it is used, patients should be warned of its potential severe complications. Also, serial liver tests should be closely monitored and, in case of elevations, the drug should be immediately withdrawn.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherMEXICAN ASSOC HEPATOLOGYes_CL
Keywordsdc.subjectFlutamidees_CL
Títulodc.titleAcute and fulminant hepatitis induced by flutamide: Case series report and review of the literaturees_CL
Document typedc.typeArtículo de revistaes_CL


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