Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia
Author
dc.contributor.author
Mendoza Inzunza, Laura
Author
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Gogali, Athena
es_CL
Author
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Shrikrishna, Dinesh
es_CL
Author
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Cavada Chacón, Gabriel
es_CL
Author
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Kemp, Samuel V.
es_CL
Author
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Natanek, Samantha A.
es_CL
Author
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Jackson, Abigail S.
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Author
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Polkey, Michael I.
es_CL
Author
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Wells, Athol U.
es_CL
Author
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Hopkinson, Nicholas S.
es_CL
Admission date
dc.date.accessioned
2014-12-18T18:15:11Z
Available date
dc.date.available
2014-12-18T18:15:11Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Respirology (2014) 19, 138–143
en_US
Identifier
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doi: 10.1111/resp.12181
Identifier
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https://repositorio.uchile.cl/handle/2250/124291
General note
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Artículo de publicación ISI
en_US
Abstract
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Background and objective: Quadriceps muscle dysfunction
is an important contributor to exercise limitation
in chronic obstructive pulmonary disease, but
little is known about skeletal muscle function and its
impact on exercise capacity in patients with fibrotic
idiopathic interstitial pneumonia (IIP). The aim of the
study was to compare quadriceps strength and endurance
in patients with fibrotic IIP and healthy controls,
and relate it to exercise capacity.
Methods: Quadriceps strengthandendurance,aswell
as respiratory muscle strength, and 6-min walk distance
were compared among 25 patients with fibrotic
IIP,forcedvital capacitymean(standarddeviation) 78.7
(14.0) %predicted, carbon monoxide transfer factor
40.3 (10.9) %predicted and 33 age-matched healthy
controls using non-volitional measures. Quadriceps
strength was assessed using magnetic femoral nerve
stimulation (quadriceps twitch force), and endurance
using the decay in force in response to repetitive magnetic
stimulation of the quadriceps over 5 min.
Results: Both groups had comparable anthropometrics,
gender proportion and respiratory muscle
strength. Patients were significantly weaker than controls;
quadriceps twitch force 10.1 (3.0) kg versus 8.0
(2.4) kg (P = 0.013). Quadriceps force in response to
repetitive magnetic stimulation declined significantly
more rapidly in patients during the endurance protocol
(P < 0.001). In controls, there was a significant relationship
between 6-min walk distance and quadriceps
twitch force (r 0.40, P = 0.038), and quadriceps endurance
(r 0.59, P = 0.016). In patients, only PaO2 and
inspiratory muscle strength were retained as independent
correlates of 6-min walk distance (r2 = 0.3
P = 0.022).
Conclusions: Quadriceps strength and endurance are
reduced in patients with fibrotic IIP compared with
healthy controls, but are less tightly correlated with
exercise performance.
en_US
Patrocinador
dc.description.sponsorship
The research was supported by the NIHR Respiratory
Disease Biomedical Research Unit at the Royal Brompton and
Harefield NHS Foundation Trust and Imperial College London,
which also part funds Professor Polkey. Abigail Jackson was
supported by The Moulton Medical Foundation, and Dinesh
Shrikrishna by The UK Medical Research Council.