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Authordc.contributor.authorAsenjo de Leuze, Juan 
Authordc.contributor.authorAndrews Farrow, Bárbara es_CL
Admission datedc.date.accessioned2010-01-28T15:24:55Z
Available datedc.date.available2010-01-28T15:24:55Z
Publication datedc.date.issued2008-02
Cita de ítemdc.identifier.citationJOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY Volume: 83 Issue: 2 Pages: 117-120 Published: FEB 2008en_US
Identifierdc.identifier.issn0268-2575
Identifierdc.identifier.other10.1002/jctb.1851
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/125273
Abstractdc.description.abstractIn this paper the issues and challenges presented 15 years ago for performing efficient separation processes for recombinant proteins are revised and discussed. Competitive advantage in production was seen as not only dependent on innovations in molecular biology and other areas of basic biological sciences but also on innovation of separations and downstream processes. The trend to develop techniques that exploit fundamental physicochemical principles more efficiently was emphasized, including analysis of the physicochemical properties of proteins and its relation to efficiency in bioseparation. 15 years ago the main thrust was also focused on the development of novel techniques. Clearly the challenges faced today, where highly optimized and efficient production processes exist, are dramatically different. The use of mathematical models for optimizing chromatographic separations and simplifying validation of such operations is extremely advantageous. Their use constitutes an example of how the challenges that bioseparations are facing and will be facing within the next few years can be met. Such models should be extended to a larger number of proteins, chromatographic procedures and experimental conditions.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherJOHN WILEYen_US
Keywordsdc.subjectPURIFICATION PROCESSESen_US
Títulodc.titleChallenges and trends in bioseparationsen_US
Document typedc.typeArtículo de revista


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