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Authordc.contributor.authorRateb, Mostafa E. 
Authordc.contributor.authorHoussen, Wael E. es_CL
Authordc.contributor.authorArnold, Markus es_CL
Authordc.contributor.authorAbdelrahman, Mostafa H. es_CL
Authordc.contributor.authorDeng, Hai es_CL
Authordc.contributor.authorHarrison, William T. A. es_CL
Authordc.contributor.authorOkoro, Chinyere K. es_CL
Authordc.contributor.authorAsenjo de Leuze, Juan es_CL
Authordc.contributor.authorAndrews Farrow, Bárbara es_CL
Authordc.contributor.authorFerguson, Gail es_CL
Authordc.contributor.authorBull, Alan T. es_CL
Authordc.contributor.authorGoodfellow, Michael es_CL
Authordc.contributor.authorEbel, Rainer es_CL
Authordc.contributor.authorJaspars, Marcel es_CL
Cita de ítemdc.identifier.citationJOURNAL OF NATURAL PRODUCTS Volume: 74 Issue: 6 Pages: 1491-1499 Published: JUN 2011en_US
Identifierdc.identifier.otherDOI: 10.1021/np200320u
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractStreptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting in the isolation and identification of four new ansamycin-type polyketides. The organism was selected for chemical investigation on the basis of a genome-mining PCR-based experiment targeting the gene encoding rifamycin-specific 3-amino- 5-hydroxybenzoic acid synthetase (AHBA). The isolated compounds were structurally characterized using NMR and MS techniques and named chaxamycins A D (1 4). Compounds 1 4 were tested for their antibacterial activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 and for their ability to inhibit the intrinsic ATPase activity of the heat shock protein 90 (Hsp90). Chaxamycin D (4), which showed a selective antibacterial activity against S. aureus ATCC 25923, was tested further against a panel of MRSA clinical isolates. In a virtual screening experiment, chaxamycins A D(1 4) have also been docked into the ATP-binding pocket in the N-terminal domain of the Hsp90, and the observed interactions are discussed.en_US
Patrocinadordc.description.sponsorshipSULSA MRC G0501107 Royal Society JP100654 Millenium Scientific Initiative ICM-P05-001-Fen_US
Publisherdc.publisherAMER CHEMICAL SOCen_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleChaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp.en_US
Document typedc.typeArtículo de revista

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile