Assessing biomarkers and neuropsychological outcomes in rural populations exposed to organophosphate pesticides in Chile – study design and protocol
Author
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Ramírez Santana, Muriel
Author
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Zúñiga, Liliana
Author
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Corral Zavala, Sebastián
Author
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Sandoval, Rodrigo
Author
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Scheepers, Paul
Author
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Van der Velden, Koos
Author
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Roeleveld, Nel
Author
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Pancetti, Floria
Admission date
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2015-08-17T20:10:24Z
Available date
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2015-08-17T20:10:24Z
Publication date
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2015
Cita de ítem
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BMC Public Health (2015) 15:116
en_US
Identifier
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DOI: 10.1186/s12889-015-1463-5
Identifier
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https://repositorio.uchile.cl/handle/2250/132792
General note
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Artículo de publicación ISI
en_US
Abstract
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Health effects of pesticides are easily diagnosed when acute poisonings occurs, nevertheless,
consequences from chronic exposure can only be observed when neuropsychiatric, neurodegenerative or
oncologic pathologies appear. Therefore, early monitoring of this type of exposure is especially relevant to avoid
the consequences of pathologies previously described; especially concerning workers exposed to pesticides on
the job. For acute organophosphate pesticides (OPP) exposure, two biomarkers have been validated: plasma
cholinesterase (ChE) and acetylcholinesterase (AChE) from erythrocytes. These enzymes become inhibited when
people are exposed to high doses of organophosphate pesticides, along with clear signs and symptoms of
acute poisoning; therefore, they do not serve to identify risk from chronic exposure. This study aims to assess a
novel biomarker that could reflect neuropsychological deterioration associated with long-term exposure to
organophosphate pesticides via the enzyme acylpeptide-hydrolase (ACPH), which has been recently identified as
a direct target of action for some organophosphate compounds.
en_US
Patrocinador
dc.description.sponsorship
The project Fondef D09I1057 was founded by FONDEF Fondo de Fomento al
Desarrollo Científico y Tecnológico, CONICYT Chile (Fund for the promotion of scientific
and technological development, National Commission for Scientific and
Technological Research, Chile).