The Price of Nonabandonment: HIV in Resource-Limited Settings
Author
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Khademi, Amin
Author
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Sauré Valenzuela, Denis
Author
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Schaefer, Andrew J.
Author
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Braithwaite, Ronald S.
Author
dc.contributor.author
Roberts, Mark S.
Admission date
dc.date.accessioned
2016-01-09T02:53:58Z
Available date
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2016-01-09T02:53:58Z
Publication date
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2015
Cita de ítem
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M&SOM-Manufacturing & Service Operations Management Volumen: 17 Número: 4 (2015)
en_US
Identifier
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DOI: 10.1287/msom.2015.0545
Identifier
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https://repositorio.uchile.cl/handle/2250/136300
General note
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Artículo de publicación ISI
en_US
Abstract
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The global fight against HIV/AIDS is hindered by a lack of drugs in the developing world. When patients in these countries initiate treatment, they typically remain on it until death; thus, policy makers and physicians follow nonabandonment policies. However, treated patients develop resistance to treatment, so in many cases untreated patients might benefit more from the drugs. In this paper we quantify the opportunity cost associated with restricting attention to nonabandonment policies. For this, we use an approximate dynamic programming framework to bound the benefit from allowing premature treatment termination. Our results indicate that in sub-Saharan Africa, the price associated with restricting attention to nonabandonment policies lies between 4.4% and 8.1% of the total treatment benefit. We also derive superior treatment allocation policies, which shed light on the role behavior and health progression play in prioritizing treatment initiation and termination.
en_US
Patrocinador
dc.description.sponsorship
National Science Foundation
CMMI-1233441
CMMI-1100082
CMMI-1333758
CMMI-1400009
Chilean Millennium Institute of Complex Engineering Systems
ICM: P05-004-F FIN. ICM-FIC