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Authordc.contributor.authorCorrea, Katharina 
Authordc.contributor.authorLhorente, Jean Paul 
Authordc.contributor.authorLópez, María E. 
Authordc.contributor.authorBassini, Liane 
Authordc.contributor.authorNaswa, Sudhir 
Authordc.contributor.authorDeeb, Nader 
Authordc.contributor.authorDi Genova, Alex 
Authordc.contributor.authorMaass Sepúlveda, Alejandro 
Authordc.contributor.authorDavidson, William S. 
Authordc.contributor.authorYáñez López, José 
Admission datedc.date.accessioned2016-03-24T02:22:50Z
Available datedc.date.available2016-03-24T02:22:50Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationBMC Genomics (2015) 16:854en_US
Identifierdc.identifier.otherDOI: 10.1186/s12864-015-2038-7
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/137382
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractBackground: Pisciricketssia salmonis is the causal agent of Salmon Rickettsial Syndrome (SRS), which affects salmon species and causes severe economic losses. Selective breeding for disease resistance represents one approach for controlling SRS in farmed Atlantic salmon. Knowledge concerning the architecture of the resistance trait is needed before deciding on the most appropriate approach to enhance artificial selection for P. salmonis resistance in Atlantic salmon. The purpose of the study was to dissect the genetic variation in the resistance to this pathogen in Atlantic salmon. Methods: 2,601 Atlantic salmon smolts were experimentally challenged against P. salmonis by means of intra-peritoneal injection. These smolts were the progeny of 40 sires and 118 dams from a Chilean breeding population. Mortalities were recorded daily and the experiment ended at day 40 post-inoculation. Fish were genotyped using a 50K Affymetrix (R) Axiom (R) myDesign (TM) Single Nucleotide Polymorphism (SNP) Genotyping Array. A Genome Wide Association Analysis was performed on data from the challenged fish. Linear regression and logistic regression models were tested. Results: Genome Wide Association Analysis indicated that resistance to P. salmonis is a moderately polygenic trait. There were five SNPs in chromosomes Ssa01 and Ssa17 significantly associated with the traits analysed. The proportion of the phenotypic variance explained by each marker is small, ranging from 0.007 to 0.045. Candidate genes including interleukin receptors and fucosyltransferase have been found to be physically linked with these genetic markers and may play an important role in the differential immune response against this pathogen. Conclusions: Due to the small amount of variance explained by each significant marker we conclude that genetic resistance to this pathogen can be more efficiently improved with the implementation of genetic evaluations incorporating genotype information from a dense SNP array.en_US
Patrocinadordc.description.sponsorshipVicerrectoria de Investigacion y Desarrollo, Universidad de Chile 11IEI-12843 CONICYT (Government of Chile) IT14I10100en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherBioMed Centralen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectSalmon Rickettsial Syndromeen_US
Keywordsdc.subjectGenome Wide Association Analysisen_US
Keywordsdc.subjectPathogen resistanceen_US
Keywordsdc.subjectAtlantic salmonen_US
Keywordsdc.subjectSingle Nucleotide Polymorphismen_US
Títulodc.titleGenome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomesen_US
Document typedc.typeArtículo de revista


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile